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A developmental ocular anomaly in which the primary vitreous body and its surrounding hyaloid vasculature failed to regress. It is usually unilateral and characterized by cataract; microphthalmos (small eyeballs), and retrolenticular fibrovascular tissue. (from Yanoff: Ophthalmology, 2nd ed.)
Estimated prevalence: Unknown (Unknown prevalence).
1 clinical trial registered, 1 recruiting. Interventions under study include medical devices. Pipeline includes 1 PHASE4. Research is primarily sponsored by academic and government institutions.
39 publications have been identified in PubMed for persistent hyperplastic primary vitreous. Research spans Case Report / Case Series (44%), Basic Science / Preclinical (38%), and Review / Meta-Analysis (8%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 17 |
Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 5:03 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Laboratory research | 15 | 38% |
Research summaries | 3 | 8% |
Disease patterns and progression | 3 | 8% |
Clinical study results | 1 | 3% |
Attademo FLN (2026). [PMID: 42165340](https://pubmed.ncbi.nlm.nih.gov/42165340/). *Vet Med Sci*. [Case Report / Case Series]
Wu Q (2026). [PMID: 41535365](https://pubmed.ncbi.nlm.nih.gov/41535365/). *Sci Rep*. [Basic Science / Preclinical]
Liu C (2026). [PMID: 41825501](https://pubmed.ncbi.nlm.nih.gov/41825501/). *J AAPOS*. [Case Report / Case Series]
Ng K (2026). [PMID: 41894212](https://pubmed.ncbi.nlm.nih.gov/41894212/). *IEEE J Biomed Health Inform*. [Basic Science / Preclinical]
da Costa Correia D (2026). [PMID: 41740732](https://pubmed.ncbi.nlm.nih.gov/41740732/). *J Biomed Inform*. [Basic Science / Preclinical]
Li X (2025). [PMID: 40113152](https://pubmed.ncbi.nlm.nih.gov/40113152/). *Methods*. [Basic Science / Preclinical]
Quarta A (2025). [PMID: 39403037](https://pubmed.ncbi.nlm.nih.gov/39403037/). *European journal of ophthalmology*. [Case Report / Case Series]
Somani N (2025). [PMID: 38166207](https://pubmed.ncbi.nlm.nih.gov/38166207/). *Retinal cases & brief reports*. [Case Report / Case Series]
Chen H (2025). [PMID: 39647568](https://pubmed.ncbi.nlm.nih.gov/39647568/). *American journal of ophthalmology*. [Clinical Trial Publication]
Otsubo M (2025). [PMID: 39029118](https://pubmed.ncbi.nlm.nih.gov/39029118/). *Retin Cases Brief Rep*. [Case Report / Case Series]
AI-curated news mentioning persistent hyperplastic primary vitreous
Updated Jun 7, 2026
A recent case report highlights the association between CHARGE syndrome and persistent hyperplastic primary vitreous, contributing to the understanding of ocular manifestations in this rare condition. This discovery may inform future research and clinical approaches to managing patients with CHARGE syndrome.