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A teratologic disorder associated with intrauterine exposure of phenorbarbital during the first trimester of pregnancy. Infants are usually asymptomatic but an increased risk of intellectual disability, tetralogy of Fallot, unilateral cleft lip, hypoplasia of the mitral valve and some other mild abnormalities such as hypertelorism, epicanthus, hypoplasia and low insertion of the nose, low insertion of the ears, prognathism, finger hypoplasia, brachydactyly and hypospadias have been reported in rare cases.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for phenobarbital embryopathy.
3 publications have been identified in PubMed for phenobarbital embryopathy. Research spans Review / Meta-Analysis (67%) and Case Report / Case Series (33%).
Han JY (2025). [PMID: 39566919](https://pubmed.ncbi.nlm.nih.gov/39566919/). *Obstetrics & gynecology science*. [Review / Meta-Analysis]
Jia Y (2024). [PMID: 39664520](https://pubmed.ncbi.nlm.nih.gov/39664520/). *Frontiers in pharmacology*. [Case Report / Case Series]
Dubucs C (2024). [PMID: 39296666](https://pubmed.ncbi.nlm.nih.gov/39296666/). *Frontiers in pediatrics*. [Review / Meta-Analysis]
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 12:11 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center