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A germinoma that arises from the pineal gland.
Biomarker and diagnostic research for pineal region germinoma has been reported in the published literature.
8 clinical trials registered, 5 recruiting. Interventions under study include procedural interventions, drug therapy, and other interventions. Pipeline includes 1 PHASE3, 2 PHASE2, 1 PHASE1. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT03158064](https://clinicaltrials.gov/study/NCT03158064) |
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 7:49 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Evaluating Immune Therapy, Duravalumab (MEDI4736) With Tremelimumab for Relapsed/Refractory Germ Cell Tumors |
PHASE2 |
Memorial Sloan Kettering Cancer Center |
ACTIVE_NOT_RECRUITING |
[NCT05982691](https://clinicaltrials.gov/study/NCT05982691) | Development of Asian Consortium for Data Collection and Clinical Trial of CNS Tumors | — | National Cancer Center, Korea | RECRUITING |
[NCT04648462](https://clinicaltrials.gov/study/NCT04648462) | Proton Therapy Research Infrastructure- ProTRAIT- Neuro-oncology | — | Maastricht Radiation Oncology | RECRUITING |
[NCT05564026](https://clinicaltrials.gov/study/NCT05564026) | Molecular Epidemiology of Pediatric Germ Cell Tumors | — | Children's Oncology Group | RECRUITING |
[NCT02375204](https://clinicaltrials.gov/study/NCT02375204) | Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors | PHASE3 | Alliance for Clinical Trials in Oncology | UNKNOWN |
99 publications have been identified in PubMed for pineal region germinoma. Kisho has analyzed 59 by research type. Research spans Case Report / Case Series (39%), Review / Meta-Analysis (20%), and Epidemiology / Natural History (19%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 23 | 39% |
Research summaries | 12 | 20% |
Disease patterns and progression | 11 | 19% |
Testing and diagnosis research | 7 | 12% |
Clinical study results | 4 | 7% |
Laboratory research | 2 | 3% |
Kanamori M (2026). [PMID: 41617963](https://pubmed.ncbi.nlm.nih.gov/41617963/). *Int J Clin Oncol*. [Clinical Trial Publication]
Saliba A (2026). [PMID: 41710768](https://pubmed.ncbi.nlm.nih.gov/41710768/). *Frontiers in child and adolescent psychiatry*. [Case Report / Case Series]
Liu AP (2025). [PMID: 41198339](https://pubmed.ncbi.nlm.nih.gov/41198339/). *Adv Cancer Res*. [Review / Meta-Analysis]
Oh J (2025). [PMID: 40136384](https://pubmed.ncbi.nlm.nih.gov/40136384/). *Curr Oncol*. [Review / Meta-Analysis]
Huang JW (2025). [PMID: 40115455](https://pubmed.ncbi.nlm.nih.gov/40115455/). *Transl Pediatr*. [Case Report / Case Series]
Dowaki R (2025). [PMID: 39854721](https://pubmed.ncbi.nlm.nih.gov/39854721/). *J Neurosurg*. [Diagnostic / Biomarker]
Koster M (2025). [PMID: 40704639](https://pubmed.ncbi.nlm.nih.gov/40704639/). *Endocrinol Diabetes Metab Case Rep*. [Case Report / Case Series]
Lee E (2025). [PMID: 40347126](https://pubmed.ncbi.nlm.nih.gov/40347126/). *Brain Tumor Res Treat*. [Diagnostic / Biomarker]
Chen Y (2025). [PMID: 39809487](https://pubmed.ncbi.nlm.nih.gov/39809487/). *BMJ Case Rep*. [Case Report / Case Series]
Park HK (2025). [PMID: 41303827](https://pubmed.ncbi.nlm.nih.gov/41303827/). *Medicina (Kaunas)*. [Epidemiology / Natural History]
AI-curated news mentioning pineal region germinoma
Updated Aug 1, 2026
A case study reports the occurrence of metachronous pineal germinoma 11 years following the total resection of a mature teratoma. This finding highlights the potential for late-onset germ cell tumors in patients with a history of teratoma.