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pituitary adenocarcinoma - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

pituitary adenocarcinoma

MONDO:0017582

Also known as:cancer of pituitarycancer of pituitary glandcancer of the pituitary

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Overview

A rare adenocarcinoma with poor prognosis, arising from the adenohypophysial cells of the anterior lobe of the pituitary gland or pre-existing adenomas. The majority are hormonally functioning neoplasms, usually producing prolactin or ACTH. The diagnosis is based on the presence of metastases. Syndromes associated with pituitary gland carcinomas include hyperprolactinemia, Cushing disease, and acromegaly.

Clinical Trials1 registered

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include always present findings: Pituitary carcinoma; and very common findings: Increased circulating prolactin concentration, Headache, Increased circulating ACTH level, and Pituitary prolactin cell adenoma and others. 22 total HPO annotations.

Organ System	Phenotype Count	Example Features
Hormones	9	Pituitary carcinoma, Pituitary prolactin cell adenoma, Pituitary corticotropic cell adenoma

Diagnosis

Biomarker and diagnostic research for pituitary adenocarcinoma has been reported in the published literature.

Prognosis

Phenotype severity distribution: 1 always present feature, 6 very common features, 5 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

1 clinical trial registered. Pipeline includes 1 PHASE2.

162 publications have been identified in PubMed for pituitary adenocarcinoma. Research spans Review / Meta-Analysis (48%), Basic Science / Preclinical (19%), and Case Report / Case Series (11%).

Research Type	Count	% of Total
Research summaries	78	48%

Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 3:07 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:300385

GARD

Genetic and Rare Diseases Info Center

GARD:9371

Questions for Your Care Team

→Are any of the 1 active clinical trial a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Kisho

pituitary adenocarcinoma

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

pituitary adenocarcinoma

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications