Orphan Drug Designations

The following drugs have received orphan drug designation from the FDA for Plasmodium falciparum malaria. Orphan designation reflects regulatory interest and does not indicate approval for treatment.

Gene therapy approaches for Plasmodium falciparum malaria have been reported in the published literature.

308 publications have been identified in PubMed for Plasmodium falciparum malaria. Kisho has analyzed 229 by research type. Research spans Basic Science / Preclinical (29%), Epidemiology / Natural History (20%), and Clinical Trial Publication (18%).

Recent Publications

• Huppertz F (2026). [PMID: 41084330](https://pubmed.ncbi.nlm.nih.gov/41084330/). *FEBS letters*. [Basic Science / Preclinical]

• González-Castillo NI (2026). [PMID: 41352519](https://pubmed.ncbi.nlm.nih.gov/41352519/). *Microb Pathog*. [Review / Meta-Analysis]

• Hajali TA (2026). [PMID: 42194890](https://pubmed.ncbi.nlm.nih.gov/42194890/). *J Clin Med*. [Diagnostic / Biomarker]

• Tshilumba SM (2026). [PMID: 42188851](https://pubmed.ncbi.nlm.nih.gov/42188851/). *Trop Med Infect Dis*. [Epidemiology / Natural History]

• Shi D (2026). [PMID: 41420060](https://pubmed.ncbi.nlm.nih.gov/41420060/). *Nature microbiology*. [Gene Therapy / Novel Therapeutics]

• Juma E (2026). [PMID: 41152149](https://pubmed.ncbi.nlm.nih.gov/41152149/). *Br J Clin Pharmacol*. [Epidemiology / Natural History]

• Nhama A (2026). [PMID: 42174576](https://pubmed.ncbi.nlm.nih.gov/42174576/). *Malar J*. [Review / Meta-Analysis]

• Emerole K (2026). [PMID: 42199685](https://pubmed.ncbi.nlm.nih.gov/42199685/). *Trop Parasitol*. [Clinical Trial Publication]

• Rajaonarimirana E (2026). [PMID: 41666420](https://pubmed.ncbi.nlm.nih.gov/41666420/). *Am J Trop Med Hyg*. [Basic Science / Preclinical]

• Cassol C (2026). [PMID: 42263924](https://pubmed.ncbi.nlm.nih.gov/42263924/). *Travel Med Infect Dis*. [Case Report / Case Series]