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The presence of pus in the thoracic cavity, between the visceral and parietal pleura.
Biomarker and diagnostic research for pleural empyema has been reported in the published literature.
Estimated prevalence: 1-5 in 10,000 (Uncommon).
12 clinical trials registered, 7 recruiting. Interventions under study include other interventions, drug therapy, procedural interventions, and medical devices. Pipeline includes 2 PHASE4, 8 NA. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT07337993](https://clinicaltrials.gov/study/NCT07337993) |
Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 3:45 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Fungal Empyema Thoracis |
NA |
University of Health Sciences Lahore |
RECRUITING |
[NCT07095361](https://clinicaltrials.gov/study/NCT07095361) | Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema | PHASE4 | University of North Carolina, Chapel Hill | RECRUITING |
[NCT05620329](https://clinicaltrials.gov/study/NCT05620329) | UNC Pleural Fluid Registry | — | UNC Lineberger Comprehensive Cancer Center | RECRUITING |
[NCT06427538](https://clinicaltrials.gov/study/NCT06427538) | Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas | NA | Vanderbilt University Medical Center | RECRUITING |
[NCT06657898](https://clinicaltrials.gov/study/NCT06657898) | Complicated Pneumonia (CP) in Children in South-East Europe | — | Aleksandar Sovtic | RECRUITING |
222 publications have been identified in PubMed for pleural empyema. Kisho has analyzed 105 by research type. Research spans Case Report / Case Series (45%), Epidemiology / Natural History (25%), and Clinical Trial Publication (15%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 47 | 45% |
Disease patterns and progression | 26 | 25% |
Clinical study results | 16 | 15% |
Research summaries | 12 | 11% |
Testing and diagnosis research | 2 | 2% |
Other research | 1 | 1% |
Laboratory research | 1 | 1% |
Lopatynsky EZ (2026). [PMID: 41685013](https://pubmed.ncbi.nlm.nih.gov/41685013/). *Cureus*. [Epidemiology / Natural History]
Soares-Aquino C (2026). [PMID: 42155127](https://pubmed.ncbi.nlm.nih.gov/42155127/). *Port J Card Thorac Vasc Surg*. [Clinical Trial Publication]
Prasad N (2026). [PMID: 41694920](https://pubmed.ncbi.nlm.nih.gov/41694920/). *Cureus*. [Case Report / Case Series]
Solano CD (2026). [PMID: 41930187](https://pubmed.ncbi.nlm.nih.gov/41930187/). *Clin Med Insights Case Rep*. [Case Report / Case Series]
Yong GKW (2026). [PMID: 41816467](https://pubmed.ncbi.nlm.nih.gov/41816467/). *J Thorac Dis*. [Epidemiology / Natural History]
Singh A (2026). [PMID: 41728532](https://pubmed.ncbi.nlm.nih.gov/41728532/). *Cureus*. [Clinical Trial Publication]
Kono A (2026). [PMID: 41486426](https://pubmed.ncbi.nlm.nih.gov/41486426/). *Perfusion*. [Case Report / Case Series]
Ramirez-Guerra YR (2026). [PMID: 41704966](https://pubmed.ncbi.nlm.nih.gov/41704966/). *Cureus*. [Case Report / Case Series]
Chaucayanqui DP (2026). [PMID: 41541894](https://pubmed.ncbi.nlm.nih.gov/41541894/). *Open Respir Arch*. [Case Report / Case Series]
Karam E (2026). [PMID: 42058320](https://pubmed.ncbi.nlm.nih.gov/42058320/). *IDCases*. [Case Report / Case Series]