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An acute purulent infection of the meninges and subarachnoid space caused by Streptococcus pneumoniae, most prevalent in children and adults over the age of 60. This illness may be associated with otitis media; mastoiditis; sinusitis; respiratory tract infections; sickle cell disease (anemia, sickle cell); skull fractures; and other disorders. Clinical manifestations include fever; headache; neck stiffness; and somnolence followed by seizures; focal neurologic deficits (notably deafness); and coma. (From Miller et al., Merritt's Textbook of Neurology, 9th ed, p111)
Biomarker and diagnostic research for pneumococcal meningitis has been reported in the published literature.
No clinical trials have been registered for pneumococcal meningitis.
194 publications have been identified in PubMed for pneumococcal meningitis. Kisho has analyzed 29 by research type. Research spans Epidemiology / Natural History (38%), Basic Science / Preclinical (17%), and Review / Meta-Analysis (14%).
Research Type | Count | % of Total |
|---|---|---|
Disease patterns and progression | 11 | 38% |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 11:54 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Laboratory research |
5 |
17% |
Research summaries | 4 | 14% |
Patient case studies | 3 | 10% |
Other research | 2 | 7% |
Clinical study results | 2 | 7% |
Testing and diagnosis research | 1 | 3% |
New treatment approaches | 1 | 3% |
West T (2026). [PMID: 41032173](https://pubmed.ncbi.nlm.nih.gov/41032173/). *Eur J Clin Microbiol Infect Dis*. [Diagnostic / Biomarker]
Wang J (2025). [PMID: 39887961](https://pubmed.ncbi.nlm.nih.gov/39887961/). *Immun Inflamm Dis*. [Basic Science / Preclinical]
Zhang Y (2025). [PMID: 40404806](https://pubmed.ncbi.nlm.nih.gov/40404806/). *Sci Rep*. [Epidemiology / Natural History]
Yang Y (2025). [PMID: 39864526](https://pubmed.ncbi.nlm.nih.gov/39864526/). *J Infect*. [Basic Science / Preclinical]
Bulaeva A (2025). [PMID: 40185548](https://pubmed.ncbi.nlm.nih.gov/40185548/). *Med Clin North Am*. [Review / Meta-Analysis]
Nordmann-Gomes A (2025). [PMID: 40749440](https://pubmed.ncbi.nlm.nih.gov/40749440/). *Semin Arthritis Rheum*. [Review / Meta-Analysis]
Sakatani H (2025). [PMID: 40823821](https://pubmed.ncbi.nlm.nih.gov/40823821/). *mBio*. [Basic Science / Preclinical]
Guillem L (2025). [PMID: 40328863](https://pubmed.ncbi.nlm.nih.gov/40328863/). *Sci Rep*. [Epidemiology / Natural History]
Giolito A (2025). [PMID: 40113367](https://pubmed.ncbi.nlm.nih.gov/40113367/). *Lancet Child Adolesc Health*. [Clinical Trial Publication]
Nguyen S (2025). [PMID: 40397876](https://pubmed.ncbi.nlm.nih.gov/40397876/). *PLoS One*. [Epidemiology / Natural History]
AI-curated news mentioning pneumococcal meningitis
Updated Jun 2, 2026
A case study highlights pneumococcal meningitis complicated by extensive cerebral venous sinus thrombosis in an immunocompromised patient. This research underscores the complexities of managing rare infections in vulnerable populations.