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A usually autosomal dominant and less frequently autosomal recessive genetic disorder characterized by the presence of numerous cysts in the kidneys leading to end-stage renal failure. The autosomal dominant trait is associated with abnormalities on the short arm of chromosome 16. Symptoms in patients with the autosomal dominant trait usually appear at middle age and include abdominal pain, hematuria, and high blood pressure. Patients may develop brain aneurysms and liver cysts. Patients with the autosomal recessive trait present with progressive renal failure early in life and symptoms resulting from hepatic fibrosis. The autosomal recessive trait is associated with abnormalities of chromosome 6. Polycystic kidney disease may also result as a side effect in patients on renal dialysis.
Biomarker and diagnostic research for polycystic kidney disease has been reported in the published literature.
54 clinical trials registered, 21 recruiting. Interventions under study include other interventions, drug therapy, biologic therapy, and medical devices. Pipeline includes 1 PHASE3, 7 PHASE2, 12 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT01401998](https://clinicaltrials.gov/study/NCT01401998) |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 3:00 PM UTC
Genetic and Rare Diseases Info Center
ARPKD Database Study |
— |
Children's Hospital of Philadelphia |
RECRUITING |
[NCT04630613](https://clinicaltrials.gov/study/NCT04630613) | NOX4 and Related Biomarkers in ADPKD | — | Mayo Clinic | RECRUITING |
[NCT00792155](https://clinicaltrials.gov/study/NCT00792155) | Polycystic Kidney Disease Data Repository | — | The Rogosin Institute | RECRUITING |
[NCT02936791](https://clinicaltrials.gov/study/NCT02936791) | Early PKD Observational Cohort Study | — | University of Kansas Medical Center | RECRUITING |
[NCT06435858](https://clinicaltrials.gov/study/NCT06435858) | Short-term Effects of an SGLT2 Inhibitor on Divalent Ions in Autosomal Dominant Polycystic Kidney Disease | PHASE2 | Cantonal Hospital Graubuenden | RECRUITING |
201 publications have been identified in PubMed for polycystic kidney disease. Kisho has analyzed 145 by research type. Research spans Review / Meta-Analysis (42%), Basic Science / Preclinical (22%), and Epidemiology / Natural History (9%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 61 | 42% |
Laboratory research | 32 | 22% |
Disease patterns and progression | 13 | 9% |
Clinical study results | 11 | 8% |
Patient case studies | 9 | 6% |
Other research | 8 | 6% |
Testing and diagnosis research | 6 | 4% |
New treatment approaches | 5 | 3% |
Rangan G (2026). [PMID: 41926217](https://pubmed.ncbi.nlm.nih.gov/41926217/). *J Am Soc Nephrol*. [Review / Meta-Analysis]
Altay D (2026). [PMID: 41567255](https://pubmed.ncbi.nlm.nih.gov/41567255/). *Pediatr Gastroenterol Hepatol Nutr*. [Diagnostic / Biomarker]
Finnigan NA (2026). [PMID: 29261941](https://pubmed.ncbi.nlm.nih.gov/29261941/). *Unknown Journal*. [Epidemiology / Natural History]
Zheng Q (2026). [PMID: 41501598](https://pubmed.ncbi.nlm.nih.gov/41501598/). *Hum Mol Genet*. [Basic Science / Preclinical]
Clerici S (2026). [PMID: 41506962](https://pubmed.ncbi.nlm.nih.gov/41506962/). *Trends Mol Med*. [Review / Meta-Analysis]
Zhang W (2026). [PMID: 42193072](https://pubmed.ncbi.nlm.nih.gov/42193072/). *Curr Issues Mol Biol*. [Review / Meta-Analysis]
Shinozaki A (2026). [PMID: 41649706](https://pubmed.ncbi.nlm.nih.gov/41649706/). *Clin Exp Nephrol*. [Case Report / Case Series]
Birznieks CL (2026). [PMID: 41911082](https://pubmed.ncbi.nlm.nih.gov/41911082/). *Kidney Blood Press Res*. [Clinical Trial Publication]
Felker SA (2026). [PMID: 41277540](https://pubmed.ncbi.nlm.nih.gov/41277540/). *Genet Med*. [Epidemiology / Natural History]
Yasinoglu SA (2026). [PMID: 41071604](https://pubmed.ncbi.nlm.nih.gov/41071604/). *J Am Soc Nephrol*. [Basic Science / Preclinical]
AI-curated news mentioning polycystic kidney disease
Updated Aug 28, 2026
Research reveals that the fibrocystin C-terminal domain inhibits Src/STAT3 signaling, which is linked to cystogenesis in kidney epithelial cells. This discovery could provide insights into therapeutic strategies for kidney diseases.
Recent research highlights the importance of kidney biopsies in accurately diagnosing kidney conditions in diabetes patients. This study aims to reduce mislabeling and improve patient outcomes by providing clearer insights into kidney pathology.
Recent research highlights the use of cell-type-specific damage scores to track disease trajectories in kidney and liver diseases through single-cell and spatial transcriptomics. This innovative approach could enhance understanding of disease progression and inform future therapeutic strategies.
Boulevard Bio has launched with $65 million in funding from Deerfield Management to develop multi-specific antibody programs targeting autoimmune diseases. The New York-based biotech aims to improve treatment for kidney disease and enhance precision immunology.
Securing funding from such a high-caliber syndicate is a strong validator of our approach to treating kidney diseases such as ADPKD. This financing will allow us to progress the clinical development of our lead candidate, bringing us closer to transforming the treatment landscape for patients with rare ... Securing funding from such a high-caliber syndicate is a strong validator of our approach to treating kidney diseases such as ADPKD. This financing will allow us to progress the clinical development of our lead candidate, bringing us closer to transforming the treatment landscape for patients with rare kidney diseases.” Paul Callaghan, Investment Director, Scottish National Investment Bank: “Our investment in Mironid reflects our commitment to backing impactful Scottish businesses with high-growth potential. Mironid exemplifies Scotland’s growing reputation for biotech innovation, developing a new treatment approach that could improve options for people living with kidney disease. Scottish National Investment Bank joins existing investors Roche Venture Fund, Epidarex Capital, Sofinnova Partners and BioGeneration Ventures · Glasgow, Scotland, August 5, 2026 – Mironid, a biopharmaceutical company developing small molecule therapeutics for the treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD), a life-threatening hereditary kidney disease, today announces it has raised $46 million in a Series B funding round. Preclinical data shows significant efficacy and a favourable safety profile across all disease endpoints, including a reduction in cyst number and kidney volume. The ability of cAMP modulators to prevent new cyst formation and arrest the growth of existing cysts is indicative of the potential to offer an effective and durable treatment option with an improved side-effect profile for all ADPKD patients. The funding round was supported by new investor the Scottish National Investment Bank and existing investors the Roche Venture Fund, Epidarex Capital, Sofinnova Partners, BioGeneration Ventures and the University of Strathclyde.