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polydactyly, postaxial, type a10 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

polydactyly, postaxial, type a10

MONDO:0032785

Also known as:PAPA10

Overview

GeneticsAutosomal recessive · KIAA0825 (chr 5)

Clinical Presentation

Features include: Postaxial polydactyly type A, Postaxial hand polydactyly, and Postaxial foot polydactyly.

Organ System	Phenotype Count	Example Features
Arms and legs	2	Postaxial hand polydactyly, Postaxial foot polydactyly

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Genetic Landscape

Assembled from HGNC gene records, ClinGen gene-disease validity evidence, and ClinVar pathogenic variant data. Validity classifications reflect the strength of published evidence linking each gene to this disease.

KIAA0825 encodes KIAA0825 (1,275 aa). Highest expression in Testis (2.4 TPM) and Brain Cerebellar Hemisphere (1.5 TPM).

Polydactyly, postaxial, type a10 is associated with mutations in the KIAA0825 gene on chromosome 5.

KIAA0825 is classified as a druggable target with score 0.0.

Diagnosis

Genetic testing for KIAA0825 is available. Testing is considered confirmatory for diagnosis.

Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 4:59 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:618498

GARD

Genetic and Rare Diseases Info Center

GARD:18178

Questions for Your Care Team

→Should my partner and I meet with a genetic counselor to discuss carrier status and family planning?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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polydactyly, postaxial, type a10

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Medical References

External Resources

OMIM

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team