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posterior urethral valve (PUV) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

posterior urethral valve

MONDO:0019640

Also known as:PUVPosterior Urethral Valvescongenital posterior urethral valves

Find Clinical TrialsTrials

Overview

Posterior urethral valve (PUV) is the most common anomaly of fetal lower urinary tract obstruction (LUTO) and is characterized by an abnormal congenital obstructing membrane that is located within the posterior urethra associated with significant obstruction of the male bladder restricting normal bladder emptying.

Clinical Trials5 registered · 3 recruiting

Diagnosis

Biomarker and diagnostic research for posterior urethral valve has been reported in the published literature.

Prognosis

Estimated prevalence: 1-9 in 100,000 (Uncommon).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

5 clinical trials registered, 3 recruiting. Interventions under study include procedural interventions, drug therapy, and other interventions. Pipeline includes 1 PHASE3, 1 PHASE2, 1 EARLY_PHASE1. Research is primarily sponsored by academic and government institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT07527442](https://clinicaltrials.gov/study/NCT07527442)

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 11:53 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:93110

GARD

Genetic and Rare Diseases Info Center

GARD:7439

Questions for Your Care Team

→Are any of the 5 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Research Type	Count	% of Total
Disease patterns and progression	26	25%
Research summaries	22	22%
Clinical study results	22	22%
Patient case studies	19	19%
Testing and diagnosis research	8	8%
Other research	3	3%
Laboratory research	2	2%

Kisho

posterior urethral valve

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Posterior urethral valve presenting as posterior urethral calculus in adult: A rare case scenario.

posterior urethral valve

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Posterior urethral valve presenting as posterior urethral calculus in adult: A rare case scenario.