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PPoma is a type of pancreatic endocrine tumor that hypersecretes pancreatic polypeptide (PP) but that does not cause a hypersecretion syndrome (is non-functioning) and instead presents with only non-specific symptoms such as weight loss, abdominal pain, jaundice, diarrhea and/or an abdominal mass, hence leading to a late diagnosis. PPoma can be associated with multiple endocrine neoplasia 1 (MEN-1).
Features include very common findings: Neoplasm of the pancreas and Neoplasm of the small intestine; and common findings: Abnormal abdomen morphology, Weight loss, Diarrhea, and Nausea and vomiting and others. 32 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Digestive system | 15 | Neoplasm of the small intestine, Diarrhea, Nausea and vomiting |
Biomarker and diagnostic research for PPoma has been reported in the published literature.
Phenotype severity distribution: 2 very common features, 10 common features.
Estimated prevalence: Unknown (Unknown prevalence).
1 clinical trial registered. Interventions under study include drug therapy. Pipeline includes 1 PHASE2. Research is primarily sponsored by academic and government institutions.
71 publications have been identified in PubMed for PPoma. Research spans Basic Science / Preclinical (51%), Review / Meta-Analysis (15%), and Case Report / Case Series (10%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 36 | 51% |
Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 4:28 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about PPoma
Hormones |
4 |
Abnormality of the thyroid gland, Elevated circulating growth hormone concentration, Pituitary adenoma |
Growth and development | 2 | Weight loss, Elevated circulating growth hormone concentration |
Lab test results | 2 | Elevated circulating growth hormone concentration, Increased circulating prolactin concentration |
Skin | 1 | Subcutaneous lipoma |
Research summaries |
11 |
15% |
Patient case studies | 7 | 10% |
Clinical study results | 6 | 8% |
New treatment approaches | 5 | 7% |
Disease patterns and progression | 4 | 6% |
Other research | 1 | 1% |
Testing and diagnosis research | 1 | 1% |
Li WM (2026). [PMID: 41695932](https://pubmed.ncbi.nlm.nih.gov/41695932/). *World journal of gastrointestinal oncology*. [Basic Science / Preclinical]
Kasajima A (2026). [PMID: 41483302](https://pubmed.ncbi.nlm.nih.gov/41483302/). *Virchows Archiv : an international journal of pathology*. [Review / Meta-Analysis]
Alam MJ (2026). [PMID: 42031088](https://pubmed.ncbi.nlm.nih.gov/42031088/). *J Pain*. [Basic Science / Preclinical]
Su L (2026). [PMID: 41993969](https://pubmed.ncbi.nlm.nih.gov/41993969/). *Biomed Rep*. [Review / Meta-Analysis]
Álvarez-Rodríguez MG (2026). [PMID: 41349749](https://pubmed.ncbi.nlm.nih.gov/41349749/). *International journal of biological macromolecules*. [Basic Science / Preclinical]
Ateiwi YA (2026). [PMID: 41722869](https://pubmed.ncbi.nlm.nih.gov/41722869/). *Diabetes research and clinical practice*. [Review / Meta-Analysis]
Chen D (2026). [PMID: 40815461](https://pubmed.ncbi.nlm.nih.gov/40815461/). *Mol Biotechnol*. [Basic Science / Preclinical]
Hu M (2026). [PMID: 42199348](https://pubmed.ncbi.nlm.nih.gov/42199348/). *Exp Ther Med*. [Review / Meta-Analysis]
Wu D (2026). [PMID: 41547146](https://pubmed.ncbi.nlm.nih.gov/41547146/). *Translational oncology*. [Case Report / Case Series]
Saigusa S (2026). [PMID: 41589245](https://pubmed.ncbi.nlm.nih.gov/41589245/). *International cancer conference journal*. [Case Report / Case Series]