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premature ovarian failure 26 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

premature ovarian failure 26

MONDO:0976129

Overview

GeneticsMGA (chr 15)

Genetic Landscape

Assembled from HGNC gene records, ClinGen gene-disease validity evidence, and ClinVar pathogenic variant data. Validity classifications reflect the strength of published evidence linking each gene to this disease.

MGA encodes MAX dimerization protein MGA (3,065 aa). Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Highest expression in Testis (14.8 TPM) and Ovary (13.5 TPM).

Premature ovarian failure 26 is associated with mutations in the MGA gene on chromosome 15.

MGA is classified as a druggable target (Transcription Factor category) with score 0.0.

Diagnosis

Genetic testing for MGA is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for premature ovarian failure 26 has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for premature ovarian failure 26.

46 publications have been identified in PubMed for premature ovarian failure 26. Research spans Review / Meta-Analysis (30%), Basic Science / Preclinical (26%), and Epidemiology / Natural History (26%).

Research Type	Count	% of Total
Research summaries	14	30%

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 3:33 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:621065

Questions for Your Care Team

→Should I pursue genetic testing for MGA, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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premature ovarian failure 26

Overview

Genetic Landscape

Diagnosis

Research Landscape

Medical References

External Resources

OMIM

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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