Comprehensive, easy-to-understand information about this condition
How we create this content →Research studies investigating treatments and therapies for this condition.
Active Trials
Total Trials
Data from ClinicalTrials.gov Jan 30, 2026
Research studies investigating treatments and therapies for this condition.
Active Trials
Total Trials
Data from ClinicalTrials.gov Jan 30, 2026
The documentation for this syndrome is limited due to its rarity and the overlap of symptoms with other liver diseases. Because it affects a relatively small population, systematic clinical studies have been scarce, leading to gaps in understanding. The complexity of the syndrome, which includes features from multiple autoimmune liver conditions, further complicates the clinical characterization.
To navigate your care, consider seeking a hepatologist with expertise in autoimmune liver diseases, as they will be familiar with the complexities of this syndrome. Additionally, while there are no identified patient organizations specifically for this condition, resources such as the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov can provide valuable information. Participating in a natural history study may also be beneficial to contribute to the understanding of this syndrome.
There are currently three orphan drugs designated for this syndrome, including Aldafermin and berberine ursodeoxycholate, among others. However, there are no active clinical trials at this time. The absence of trials indicates a need for further research to explore treatment options. For more information on potential clinical trials in related conditions, you can search on ClinicalTrials.gov.
Actionable guidance for navigating care for primary biliary cholangitis/primary sclerosing cholangitis and autoimmune hepatitis overlap syndrome
To navigate your care, consider seeking a hepatologist with expertise in autoimmune liver diseases, as they will be familiar with the complexities of this syndrome. Additionally, while there are no identified patient organizations specifically for this condition, resources such as the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov can provide valuable information. Participating in a natural history study may also be beneficial to contribute to the understanding of this syndrome.
Consider asking your healthcare providers these condition-specific questions
Helpful links for rare disease information and support
Clinical profile data for this condition is not yet available. Phenotype information may still be loading below.
Research studies investigating treatments and therapies for this condition.
Active Trials
Total Trials
Data from ClinicalTrials.gov Jan 30, 2026
Consider asking your healthcare providers these condition-specific questions
European rare disease database
Genetic and Rare Diseases Info Center
AI-Generated Content: This summary was generated using AI. Content has been fact-checked. Always consult with qualified healthcare providers for medical guidance.
Organizations with approved therapies for this disease
No approved therapies yet
Research is ongoing — 3 companies have orphan drug designations for this disease
Kisho delivers this disease record via API, including phenotypes (HPO), genes, orphan drug designations, screening status, and PAG mapping, with version history and governance.