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A rare non-Hodgkin lymphoma or even more rarely, a Hodgkin lymphoma that arises from the bone, without lymph node or other extranodal involvement. The femur, spine, and pelvic bones are the most commonly affected sites. The majority of patients present with bone pain in the affected area. A single bone or multiple skeletal sites may be involved. The prognosis is related to the cell type and the stage of the disease.
Biomarker and diagnostic research for primary bone lymphoma has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for primary bone lymphoma.
139 publications have been identified in PubMed for primary bone lymphoma. Kisho has analyzed 107 by research type. Research spans Review / Meta-Analysis (24%), Case Report / Case Series (22%), and Basic Science / Preclinical (21%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 26 | 24% |
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 7:12 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Patient case studies
24 |
22% |
Laboratory research | 23 | 21% |
Disease patterns and progression | 14 | 13% |
Testing and diagnosis research | 9 | 8% |
Clinical study results | 7 | 7% |
New treatment approaches | 4 | 4% |
Cao Y (2026). [PMID: 41672065](https://pubmed.ncbi.nlm.nih.gov/41672065/). *Cell Rep Med*. [Basic Science / Preclinical]
Erdem A (2026). [PMID: 41673169](https://pubmed.ncbi.nlm.nih.gov/41673169/). *Nat Cell Biol*. [Review / Meta-Analysis]
Kamei N (2026). [PMID: 41769179](https://pubmed.ncbi.nlm.nih.gov/41769179/). *Radiol Case Rep*. [Case Report / Case Series]
Amahtil M (2026). [PMID: 42169973](https://pubmed.ncbi.nlm.nih.gov/42169973/). *Trauma Case Rep*. [Case Report / Case Series]
Gerards NR (2026). [PMID: 40824452](https://pubmed.ncbi.nlm.nih.gov/40824452/). *Eur J Nucl Med Mol Imaging*. [Diagnostic / Biomarker]
Fahmy V (2026). [PMID: 42116949](https://pubmed.ncbi.nlm.nih.gov/42116949/). *Cureus*. [Case Report / Case Series]
Johnson-Arbor K (2026). [PMID: 29083582](https://pubmed.ncbi.nlm.nih.gov/29083582/). *Unknown Journal*. [Basic Science / Preclinical]
Verhasselt A (2026). [PMID: 41391566](https://pubmed.ncbi.nlm.nih.gov/41391566/). *Mod Pathol*. [Diagnostic / Biomarker]
Prakash D (2026). [PMID: 35881729](https://pubmed.ncbi.nlm.nih.gov/35881729/). *Unknown Journal*. [Basic Science / Preclinical]
Jaka RC (2026). [PMID: 42082266](https://pubmed.ncbi.nlm.nih.gov/42082266/). *BMJ Case Rep*. [Case Report / Case Series]
AI-curated news mentioning primary bone lymphoma
Updated May 4, 2026
A case study highlights primary lymphoma of the acromion as a rare cause of isolated shoulder pain. This discovery emphasizes the need for awareness of atypical presentations in lymphoma diagnosis.