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Features include: Difficulty swallowing (dysphagia), Spastic dysarthria, Babinski sign, and Spastic tetraparesis and 3 more.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Brain and nerves | 6 | Difficulty swallowing (dysphagia), Spastic dysarthria, Babinski sign |
Biomarker and diagnostic research for primary lateral sclerosis, adult, 1 has been reported in the published literature.
No clinical trials have been registered for primary lateral sclerosis, adult, 1.
292 publications have been identified in PubMed for primary lateral sclerosis, adult, 1. Kisho has analyzed 104 by research type. Research spans Epidemiology / Natural History (28%), Basic Science / Preclinical (25%), and Clinical Trial Publication (22%).
Research Type | Count | % of Total |
|---|---|---|
Disease patterns and progression | 29 | 28% |
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 8:59 AM UTC
Online Mendelian Inheritance in Man
1 |
Difficulty swallowing (dysphagia) |
Laboratory research |
26 |
25% |
Clinical study results | 23 | 22% |
Testing and diagnosis research | 15 | 14% |
Research summaries | 5 | 5% |
New treatment approaches | 5 | 5% |
Patient case studies | 1 | 1% |
Fang C (2026). [PMID: 41535829](https://pubmed.ncbi.nlm.nih.gov/41535829/). *BMC Med*. [Diagnostic / Biomarker]
Saldanha-Castro P (2026). [PMID: 42013513](https://pubmed.ncbi.nlm.nih.gov/42013513/). *J Neurol Sci*. [Epidemiology / Natural History]
Chalitsios CV (2026). [PMID: 41165081](https://pubmed.ncbi.nlm.nih.gov/41165081/). *Ann Neurol*. [Diagnostic / Biomarker]
Vasta R (2026). [PMID: 41316718](https://pubmed.ncbi.nlm.nih.gov/41316718/). *Ann Neurol*. [Epidemiology / Natural History]
Dulski J (2026). [PMID: 40873038](https://pubmed.ncbi.nlm.nih.gov/40873038/). *HGG Adv*. [Diagnostic / Biomarker]
Guise AJ (2026). [PMID: 41850233](https://pubmed.ncbi.nlm.nih.gov/41850233/). *Cell Rep Med*. [Clinical Trial Publication]
Dave BR (2026). [PMID: 41664730](https://pubmed.ncbi.nlm.nih.gov/41664730/). *Cureus*. [Review / Meta-Analysis]
Miller TM (2026). [PMID: 41661214](https://pubmed.ncbi.nlm.nih.gov/41661214/). *JAMA Neurol*. [Clinical Trial Publication]
Cudkowicz M (2026). [PMID: 41837970](https://pubmed.ncbi.nlm.nih.gov/41837970/). *JAMA Neurol*. [Clinical Trial Publication]
Tarutani A (2026). [PMID: 41486180](https://pubmed.ncbi.nlm.nih.gov/41486180/). *Acta Neuropathol Commun*. [Basic Science / Preclinical]
AI-curated news mentioning primary lateral sclerosis, adult, 1
Updated Aug 1, 2026
A population-based study reveals early cognitive and behavioral changes in patients with primary lateral sclerosis, highlighting the need for early intervention strategies. This research contributes to understanding the disease's progression and potential therapeutic targets.
A new French national diagnostic and care protocol for primary lateral sclerosis has been established, aiming to standardize patient management and improve outcomes. This protocol addresses the need for consistent care in a rare disease with limited treatment options.