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Primary localized amyloidosis is a form of AL amyloidosis caused by the aggregation of insoluble amyloid fibrils derived from misfolded monoclonal immunoglobulin light chains usually produced by a plasma cell tumor and characterized by localized amyloid deposition with clinical manifestations restricted to the organ involved, most frequently urinary tract (bladder), eye, respiratory tract (larynx, lungs), and skin.
Biomarker and diagnostic research for primary localized amyloidosis has been reported in the published literature.
No clinical trials have been registered for primary localized amyloidosis.
88 publications have been identified in PubMed for primary localized amyloidosis. Kisho has analyzed 53 by research type. Research spans Case Report / Case Series (36%), Review / Meta-Analysis (19%), and Epidemiology / Natural History (13%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 19 | 36% |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 8:36 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Research summaries |
10 |
19% |
Disease patterns and progression | 7 | 13% |
Laboratory research | 6 | 11% |
Testing and diagnosis research | 5 | 9% |
Other research | 3 | 6% |
Clinical study results | 3 | 6% |
Kojimahara S (2027). [PMID: 42111927](https://pubmed.ncbi.nlm.nih.gov/42111927/). *DEN Open*. [Case Report / Case Series]
Lavall D (2026). [PMID: 41586856](https://pubmed.ncbi.nlm.nih.gov/41586856/). *Clin Res Cardiol*. [Epidemiology / Natural History]
Majumdar B (2026). [PMID: 42252573](https://pubmed.ncbi.nlm.nih.gov/42252573/). *Orbit*. [Case Report / Case Series]
Kessler L (2026). [PMID: 41653266](https://pubmed.ncbi.nlm.nih.gov/41653266/). *Eur J Nucl Med Mol Imaging*. [Epidemiology / Natural History]
Mir TH (2026). [PMID: 41740896](https://pubmed.ncbi.nlm.nih.gov/41740896/). *J Am Acad Dermatol*. [Other]
Timsina J (2026). [PMID: 42014397](https://pubmed.ncbi.nlm.nih.gov/42014397/). *Nat Commun*. [Review / Meta-Analysis]
Cervantes CE (2026). [PMID: 38865984](https://pubmed.ncbi.nlm.nih.gov/38865984/). *Am J Nephrol*. [Review / Meta-Analysis]
Farid KMN (2026). [PMID: 42257734](https://pubmed.ncbi.nlm.nih.gov/42257734/). *Inn Med (Heidelb)*. [Basic Science / Preclinical]
Connor T (2026). [PMID: 37276294](https://pubmed.ncbi.nlm.nih.gov/37276294/). *Unknown Journal*. [Diagnostic / Biomarker]
Lee HC (2026). [PMID: 41387038](https://pubmed.ncbi.nlm.nih.gov/41387038/). *Clin Lymphoma Myeloma Leuk*. [Clinical Trial Publication]
AI-curated news mentioning primary localized amyloidosis
Updated Aug 6, 2026
A recent study highlights the occurrence of cardiac tamponade due to lymphocytic constrictive pericarditis in patients with primary AL amyloidosis, even in the absence of myocardial involvement. This finding may influence future diagnostic and treatment approaches for this rare condition.
A case report details a decade-long progression of localized amyloidosis from the larynx to the nasal cavity, highlighting the disease's potential for significant anatomical impact. This study contributes to the understanding of amyloidosis and its clinical implications.