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Primary orthostatic tremor (POT), or ``shaky legs syndrome'', is a rare movement disorder characterized by fast, task-specific tremor, affecting the legs and trunk while standing.
Biomarker and diagnostic research for primary orthostatic tremor has been reported in the published literature.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
1 clinical trial registered. Interventions under study include medical devices. Pipeline includes 1 NA. Research is primarily sponsored by academic and government institutions.
17 publications have been identified in PubMed for primary orthostatic tremor. Research spans Epidemiology / Natural History (29%), Basic Science / Preclinical (18%), and Review / Meta-Analysis (12%).
Research Type | Count | % of Total |
|---|---|---|
Disease patterns and progression | 5 |
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 1:01 PM UTC
Patient Advocacy Groups (PAGs) provide support, resources, and community for patients and caregivers.
European rare disease database
Genetic and Rare Diseases Info Center
Laboratory research | 3 | 18% |
Research summaries | 2 | 12% |
Patient case studies | 2 | 12% |
Clinical study results | 2 | 12% |
Other research | 1 | 6% |
Testing and diagnosis research | 1 | 6% |
New treatment approaches | 1 | 6% |
Jesuthasan A (2026). [PMID: 41591552](https://pubmed.ncbi.nlm.nih.gov/41591552/). *J Neurol*. [Epidemiology / Natural History]
Immanni GS (2026). [PMID: 41868282](https://pubmed.ncbi.nlm.nih.gov/41868282/). *Tremor Other Hyperkinet Mov (N Y)*. [Epidemiology / Natural History]
Af Edholm K (2026). [PMID: 40747937](https://pubmed.ncbi.nlm.nih.gov/40747937/). *Mov Disord Clin Pract*. [Basic Science / Preclinical]
Babeliowsky WA (2026). [PMID: 41885046](https://pubmed.ncbi.nlm.nih.gov/41885046/). *Mov Disord Clin Pract*. [Epidemiology / Natural History]
Af Edholm K (2026). [PMID: 41798182](https://pubmed.ncbi.nlm.nih.gov/41798182/). *Tremor Other Hyperkinet Mov (N Y)*. [Clinical Trial Publication]
Af Edholm K (2026). [PMID: 41809247](https://pubmed.ncbi.nlm.nih.gov/41809247/). *BMJ Neurol Open*. [Basic Science / Preclinical]
Dao Pei Z (2025). [PMID: 41103515](https://pubmed.ncbi.nlm.nih.gov/41103515/). *Front Neurol*. [Review / Meta-Analysis]
Edholm KA (2025). [PMID: 41472715](https://pubmed.ncbi.nlm.nih.gov/41472715/). *Clin Neurophysiol Pract*. [Basic Science / Preclinical]
Azoidou V (2025). [PMID: 40809990](https://pubmed.ncbi.nlm.nih.gov/40809990/). *Clin Park Relat Disord*. [Gene Therapy / Novel Therapeutics]
Af Edholm K (2025). [PMID: 40488238](https://pubmed.ncbi.nlm.nih.gov/40488238/). *Mov Disord*. [Other]
AI-curated news mentioning primary orthostatic tremor
Updated Mar 5, 2026
A comprehensive clinical assessment of patients with primary orthostatic tremor in Sweden reveals key characteristics of this rare condition. The study enhances understanding of the clinical presentation and may inform future research and treatment strategies.