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progressive supranuclear palsy-progressive non-fluent aphasia syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

progressive supranuclear palsy-progressive non-fluent aphasia syndrome

MONDO:0016564

Also known as:PSP-AOSPSP-PNFAprogressive supranuclear palsy-apraxia of speech syndrome

Overview

PSP-progressive non fluent aphasia (PSP-PNFA) is an atypical variant of progressive supranuclear palsy (PSP), a rare late-onset neurodegenerative disease. Unlike classic PSP (Richardson syndrome) patients present with an isolated speech production problem years before developing other motor features of PSP.

Diagnosis

Biomarker and diagnostic research for progressive supranuclear palsy-progressive non-fluent aphasia syndrome has been reported in the published literature.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for progressive supranuclear palsy-progressive non-fluent aphasia syndrome.

36 publications have been identified in PubMed for progressive supranuclear palsy-progressive non-fluent aphasia syndrome. Research spans Epidemiology / Natural History (22%), Diagnostic / Biomarker (19%), and Basic Science / Preclinical (19%).

Research Type	Count	% of Total
Disease patterns and progression	8	22%

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 8:31 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:240112

GARD

Genetic and Rare Diseases Info Center

GARD:20649

Questions for Your Care Team

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progressive supranuclear palsy-progressive non-fluent aphasia syndrome

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications