Kisho

Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy

progressive transformation of germinal centers - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

progressive transformation of germinal centers

MONDO:0043346

Also known as:progressive transformation of Germinal centresPTGC

Overview

Progressive transformation of germinal centers is a condition in which a lymph node becomes very enlarged (lymphadenopathy). Typically, only one lymph node is affected, though PTGC can involve multiple lymph nodes. Theneck is the most common location of affected lymph nodes, but PTGC may also affect lymph nodes in the groin and armpits. adults are more frequently affected than children, but children have a higher chance of developing PTGC multiple times (recurrence). PTGC is not considered a precancerous condition, though it has been associated with Hodgkin lymphoma.

ResearchLimited published research (8 articles)

Diagnosis

Biomarker and diagnostic research for progressive transformation of germinal centers has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for progressive transformation of germinal centers.

8 publications have been identified in PubMed for progressive transformation of germinal centers. Research spans Review / Meta-Analysis (38%), Case Report / Case Series (38%), and Other (13%).

Recent Publications

Ben Lamine C (2026). [PMID: 42283520](https://pubmed.ncbi.nlm.nih.gov/42283520/). *Hematol Oncol Stem Cell Ther*. [Diagnostic / Biomarker]
Bosch-Schips J (2026). [PMID: 41611915](https://pubmed.ncbi.nlm.nih.gov/41611915/). *Pathologie (Heidelb)*. [Review / Meta-Analysis]
Yoshida H (2026). [PMID: 42240075](https://pubmed.ncbi.nlm.nih.gov/42240075/). *Pediatr Int*. [Case Report / Case Series]
Keyrouz E (2026). [PMID: 41909388](https://pubmed.ncbi.nlm.nih.gov/41909388/). *Cureus*. [Review / Meta-Analysis]
Kubo T (2025). [PMID: 40301080](https://pubmed.ncbi.nlm.nih.gov/40301080/). *J Clin Exp Hematop*. [Case Report / Case Series]

Data assembled from 2 of 12 sources · Last updated Sep 20, 2026, 5:51 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

GARD

Genetic and Rare Diseases Info Center

GARD:10712

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

progressive transformation of germinal centers

Overview

Diagnosis

Research Landscape

Recent Publications

Medical References

External Resources

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team