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Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene.
Features include always present findings: Prostate cancer.
RNASEL function has not been fully characterized.
Prostate cancer, hereditary, 1 is associated with mutations in the RNASEL gene on chromosome 1.
Genetic testing for RNASEL is available. Testing is considered confirmatory for diagnosis.
Biomarker and diagnostic research for prostate cancer, hereditary, 1 has been reported in the published literature.
Phenotype severity distribution: 1 always present feature.
No clinical trials have been registered for prostate cancer, hereditary, 1.
26 publications have been identified in PubMed for prostate cancer, hereditary, 1. Research spans Epidemiology / Natural History (52%), Review / Meta-Analysis (16%), and Clinical Trial Publication (12%).
Research Type | Count | % of Total |
|---|---|---|
Disease patterns and progression | 13 | 52% |
Data assembled from 5 of 12 sources · Last updated Nov 3, 2026, 11:14 AM UTC
Online Mendelian Inheritance in Man
Genetic and Rare Diseases Info Center
Research summaries
4 |
16% |
Clinical study results | 3 | 12% |
Laboratory research | 3 | 12% |
Testing and diagnosis research | 1 | 4% |
New treatment approaches | 1 | 4% |
Lanzafame H (2026). [PMID: 41714122](https://pubmed.ncbi.nlm.nih.gov/41714122/). *J Nucl Med*. [Epidemiology / Natural History]
Lee D (2026). [PMID: 41512080](https://pubmed.ncbi.nlm.nih.gov/41512080/). *Sci Immunol*. [Review / Meta-Analysis]
Hasenböhler A (2026). [PMID: 41500678](https://pubmed.ncbi.nlm.nih.gov/41500678/). *BMJ*. [Epidemiology / Natural History]
Howard TP (2026). [PMID: 41529791](https://pubmed.ncbi.nlm.nih.gov/41529791/). *Int J Radiat Oncol Biol Phys*. [Clinical Trial Publication]
Harry J (2025). [PMID: 39919489](https://pubmed.ncbi.nlm.nih.gov/39919489/). *Cancer Epidemiol*. [Review / Meta-Analysis]
Lee SY (2025). [PMID: 40530565](https://pubmed.ncbi.nlm.nih.gov/40530565/). *Sci Prog*. [Epidemiology / Natural History]
Tsukahara S (2025). [PMID: 40716035](https://pubmed.ncbi.nlm.nih.gov/40716035/). *Cancer Med*. [Basic Science / Preclinical]
Qu B (2025). [PMID: 40566486](https://pubmed.ncbi.nlm.nih.gov/40566486/). *Life (Basel)*. [Epidemiology / Natural History]
Byrne L (2025). [PMID: 40533153](https://pubmed.ncbi.nlm.nih.gov/40533153/). *J Med Genet*. [Clinical Trial Publication]
Perletti G (2025). [PMID: 40503579](https://pubmed.ncbi.nlm.nih.gov/40503579/). *Arch Ital Urol Androl*. [Review / Meta-Analysis]
AI-curated news mentioning prostate cancer, hereditary, 1
Updated Oct 22, 2026
New research identifies circulating immune and cancer driver gene biomarkers that can precede prostate cancer diagnosis by over 10 years. This discovery could enhance early detection strategies for prostate cancer.
A case report highlights the detection of a balanced double aortic arch in an octogenarian with advanced prostate cancer using 18F-FDG PET/CT. This finding underscores the importance of advanced imaging techniques in identifying rare vascular anomalies in older patients.
Research indicates that PYGO2 ablation enhances lymphoid organization and stimulates STING-dependent antitumor immunity in prostate cancer. This discovery could inform future therapeutic strategies targeting immune responses in cancer treatment.
Radiopharm Theranostics received a positive recommendation from the Data Safety and Monitoring Committee to advance to Cohort 4 in the Phase 1 HEAT clinical trial for 177Lu-RAD202. This trial is part of their innovative pipeline targeting various solid tumor cancers, including lung, breast, and prostate cancers.