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Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene.
Features include always present findings: Prostate cancer.
RNASEL function has not been fully characterized.
Prostate cancer, hereditary, 1 is associated with mutations in the RNASEL gene on chromosome 1.
Genetic testing for RNASEL is available. Testing is considered confirmatory for diagnosis.
Biomarker and diagnostic research for prostate cancer, hereditary, 1 has been reported in the published literature.
Phenotype severity distribution: 1 always present feature.
No clinical trials have been registered for prostate cancer, hereditary, 1.
26 publications have been identified in PubMed for prostate cancer, hereditary, 1. Research spans Epidemiology / Natural History (52%), Review / Meta-Analysis (16%), and Clinical Trial Publication (12%).
Research Type | Count | % of Total |
|---|---|---|
Disease patterns and progression | 13 | 52% |
Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 8:52 AM UTC
Online Mendelian Inheritance in Man
Genetic and Rare Diseases Info Center
Research summaries
4 |
16% |
Clinical study results | 3 | 12% |
Laboratory research | 3 | 12% |
Testing and diagnosis research | 1 | 4% |
New treatment approaches | 1 | 4% |
Lanzafame H (2026). [PMID: 41714122](https://pubmed.ncbi.nlm.nih.gov/41714122/). *J Nucl Med*. [Epidemiology / Natural History]
Lee D (2026). [PMID: 41512080](https://pubmed.ncbi.nlm.nih.gov/41512080/). *Sci Immunol*. [Review / Meta-Analysis]
Hasenböhler A (2026). [PMID: 41500678](https://pubmed.ncbi.nlm.nih.gov/41500678/). *BMJ*. [Epidemiology / Natural History]
Howard TP (2026). [PMID: 41529791](https://pubmed.ncbi.nlm.nih.gov/41529791/). *Int J Radiat Oncol Biol Phys*. [Clinical Trial Publication]
Harry J (2025). [PMID: 39919489](https://pubmed.ncbi.nlm.nih.gov/39919489/). *Cancer Epidemiol*. [Review / Meta-Analysis]
Lee SY (2025). [PMID: 40530565](https://pubmed.ncbi.nlm.nih.gov/40530565/). *Sci Prog*. [Epidemiology / Natural History]
Tsukahara S (2025). [PMID: 40716035](https://pubmed.ncbi.nlm.nih.gov/40716035/). *Cancer Med*. [Basic Science / Preclinical]
Qu B (2025). [PMID: 40566486](https://pubmed.ncbi.nlm.nih.gov/40566486/). *Life (Basel)*. [Epidemiology / Natural History]
Byrne L (2025). [PMID: 40533153](https://pubmed.ncbi.nlm.nih.gov/40533153/). *J Med Genet*. [Clinical Trial Publication]
Perletti G (2025). [PMID: 40503579](https://pubmed.ncbi.nlm.nih.gov/40503579/). *Arch Ital Urol Androl*. [Review / Meta-Analysis]
AI-curated news mentioning prostate cancer, hereditary, 1
Updated Aug 20, 2026
Radiopharm Theranostics received a positive recommendation from the Data Safety and Monitoring Committee to advance to Cohort 4 in the Phase 1 HEAT clinical trial for 177Lu-RAD202. This trial is part of their innovative pipeline targeting various solid tumor cancers, including lung, breast, and prostate cancers.
A multicenter study analyzed the effectiveness of stereotactic radiotherapy for rib metastases from prostate cancer, focusing on local control, pain response, and treatment tolerance. The findings contribute to understanding treatment options for patients with metastatic prostate cancer.
A study identifies subclonal complete loss of CDKN1B as a prevalent genomic alteration in prostate cancer, highlighting its associations with race and patient outcomes. This discovery may inform future research and treatment strategies in prostate cancer management.
A case report highlights penile metastasis from castration-resistant prostate cancer, providing insights into this rare occurrence. This study contributes to the understanding of metastatic patterns in advanced prostate cancer.
Pfizer presented several late-breaking data at ASCO, highlighting advancements in lung, colorectal, and prostate cancer. However, the most significant results are anticipated later this year.