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pseudoxanthoma elasticum-like papillary dermal elastolysis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

pseudoxanthoma elasticum-like papillary dermal elastolysis

MONDO:0016448

Also known as:PXE-PDEPXE-like papillary dermal elastolysis

Overview

Pseudoxanthoma elasticum-like papillary dermal elastolysis (PXE-PDE) is a rare, acquired, idiopathic dermal tissue disorder characterized by numerous, asymptomatic, 2-3 mm, yellowish, non-follicular papules that tend to converge into cobblestone-like plaques which are distributed symmetrically over the posterior neck, supraclavicular region, axillae, and sometimes abdomen. Unlike PXE, these skin lesions show select elimination (absence or marked loss) of elastic fibers in the papillary dermis and there is no systemic involvement.

ResearchLimited published research (4 articles)

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for pseudoxanthoma elasticum-like papillary dermal elastolysis.

4 publications have been identified in PubMed for pseudoxanthoma elasticum-like papillary dermal elastolysis. Research spans Case Report / Case Series (100%).

Recent Publications

Alshehri N (2025). [PMID: 41036178](https://pubmed.ncbi.nlm.nih.gov/41036178/). *Clinical, cosmetic and investigational dermatology*. [Case Report / Case Series]
El Jalkh J (2025). [PMID: 40407483](https://pubmed.ncbi.nlm.nih.gov/40407483/). *Dermatopathology (Basel, Switzerland)*. [Case Report / Case Series]
Murshidi R (2024). [PMID: 39680970](https://pubmed.ncbi.nlm.nih.gov/39680970/). *Dermatology online journal*. [Case Report / Case Series]
Ingrassia JP (2024). [PMID: 39644468](https://pubmed.ncbi.nlm.nih.gov/39644468/). *Dermatology online journal*. [Case Report / Case Series]

Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 4:30 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:228293

GARD

Genetic and Rare Diseases Info Center

GARD:20588

Questions for Your Care Team

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pseudoxanthoma elasticum-like papillary dermal elastolysis

Overview

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team