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A usually benign and self-limited skin disorder of unknown etiology, characterized by induration of the skin. It may be associated with infection, diabetes mellitus, and hematologic malignancies. Morphologically, there is deposition of mucin in the dermis.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for scleredema adultorum.
7 publications have been identified in PubMed for scleredema adultorum. Research spans Case Report / Case Series (71%) and Review / Meta-Analysis (29%).
Marcolongo D (2026). [PMID: 41821724](https://pubmed.ncbi.nlm.nih.gov/41821724/). *EJHaem*. [Case Report / Case Series]
Hemrajani P (2025). [PMID: 39836556](https://pubmed.ncbi.nlm.nih.gov/39836556/). *Advances in skin & wound care*. [Case Report / Case Series]
Sumanth TS (2025). [PMID: 41170976](https://pubmed.ncbi.nlm.nih.gov/41170976/). *Journal of the Turkish German Gynecological Association*. [Case Report / Case Series]
Tawanwongsri W (2025). [PMID: 41149080](https://pubmed.ncbi.nlm.nih.gov/41149080/). *Diseases (Basel, Switzerland)*. [Review / Meta-Analysis]
Kalantari Y (2025). [PMID: 41030177](https://pubmed.ncbi.nlm.nih.gov/41030177/). *Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG*. [Review / Meta-Analysis]
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 1:39 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Hajiani Ghotbabadi S (2025). [PMID: 41356652](https://pubmed.ncbi.nlm.nih.gov/41356652/). *Clinical case reports*. [Case Report / Case Series]
Makary N (2024). [PMID: 39167810](https://pubmed.ncbi.nlm.nih.gov/39167810/). *The New England journal of medicine*. [Case Report / Case Series]
AI-curated news mentioning scleredema adultorum
Updated Mar 11, 2026
A case report highlights the successful treatment of scleredema associated with IgG/κ monoclonal gammopathy using daratumumab monotherapy. This finding contributes to the understanding of treatment options for this rare condition.