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seronegative autoimmune hepatitis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

seronegative autoimmune hepatitis

MONDO:0035400

Also known as:Seronegative AIHautoantibody-negative autoimmune hepatitis

Overview

A form of autoimmune hepatitis characterized by the features of classic autoimmune hepatitis (i. e. clinical presentation as acute or chronic cryptogenic hepatitis, interface hepatitis on histological examination, elevated serum aspartate aminotransferase and alanine aminotransferase levels, hypergammaglobulinemia/elevated immunoglobulin G, therapeutic response to corticosteroids) in the absence of serum autoantibodies. Clinical manifestations include fatigue, malaise, arthralgia, jaundice, at later stages also signs of advanced chronic liver disease, such as spider nevi, caput medusae, splenomegaly, ascites, and palmar erythema. Presence of concurrent autoimmune diseases is frequently observed.

Diagnosis

Biomarker and diagnostic research for seronegative autoimmune hepatitis has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for seronegative autoimmune hepatitis.

11 publications have been identified in PubMed for seronegative autoimmune hepatitis. Research spans Case Report / Case Series (45%), Epidemiology / Natural History (18%), and Other (9%).

Research Type	Count	% of Total
Patient case studies	5	45%

Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 7:44 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:563589

GARD

Genetic and Rare Diseases Info Center

GARD:22253

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seronegative autoimmune hepatitis

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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