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severe hemophilia B - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

severe hemophilia B

MONDO:0015715

Also known as:severe factor IX deficiencysevere haemophilia type Bsevere hemophilia type B

Find Clinical TrialsTrials

Overview

Severe hemophilia B is a form of hemophilia B characterized by a large deficiency of factor IX leading to frequent spontaneous hemorrhage and abnormal bleeding as a result of minor injuries, or following surgery or tooth extraction.

Clinical Trials6 registered · 4 recruiting

Diagnosis

Biomarker and diagnostic research for severe hemophilia B has been reported in the published literature.

Prognosis

Estimated prevalence: 1-9 in 1,000,000 (Rare).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

6 clinical trials registered, 4 recruiting. Interventions under study include drug therapy, gene therapy, and biologic therapy. Pipeline includes 5 PHASE3, 1 PHASE1. Research is primarily industry-sponsored.

NCT ID	Title	Phase	Sponsor	Status
[NCT03861273](https://clinicaltrials.gov/study/NCT03861273)

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 6:54 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Patient Support

Financial & Access Support (External Programs)

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Hemophilia Program

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Medical References

External Resources

Orphanet

European rare disease database

Orphanet:169793

GARD

Genetic and Rare Diseases Info Center

GARD:17056

Questions for Your Care Team

→Are any of the 6 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Research Type	Count	% of Total
Disease patterns and progression	25	31%
Clinical study results	13	16%
Patient case studies	12	15%
Research summaries	11	14%
Laboratory research	9	11%
New treatment approaches	5	6%
Other research	4	5%
Testing and diagnosis research	1	1%

severe hemophilia B

Overview

Diagnosis

Prognosis

Research Landscape

Patient Support

Financial & Access Support (External Programs)

Are you a patient organization for this condition?

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications