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skin pilomatrix carcinoma - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

skin pilomatrix carcinoma

MONDO:0003414

Also known as:Pilomatrical carcinomaTrichomatrical carcinomacalcified epithelial carcinoma of Malherbe

Overview

A very rare, locally aggressive, malignant neoplasm of the hair follicle. The majority of the cases arise de novo, however malignant transformation from a pre-existing pilomatricoma has been reported. It usually presents as a solitary nodule in the head and neck, upper extremities, or buttocks. Morphologically, it is characterized by the presence of aggregates of basaloid cells infiltrating the dermis. Masses of ghost cells are present in the cellular aggregates. Complete surgical excision is the treatment of choice. If it is not completely removed, it usually recurs, but it rarely metastasizes to distant anatomic sites.

Diagnosis

Biomarker and diagnostic research for skin pilomatrix carcinoma has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for skin pilomatrix carcinoma.

21 publications have been identified in PubMed for skin pilomatrix carcinoma. Research spans Case Report / Case Series (57%), Review / Meta-Analysis (24%), and Other (5%).

Research Type	Count	% of Total
Patient case studies	12	57%

Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 11:56 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:499182

GARD

Genetic and Rare Diseases Info Center

GARD:22042

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skin pilomatrix carcinoma

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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