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spermatogenic failure 25 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

spermatogenic failure 25

MONDO:0054729

Also known as:SPGF25

Overview

GeneticsAutosomal recessive · TEX15 (chr 8)

ResearchLimited published research (7 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include always present findings: Male infertility, Decreased testicular size, and Spermatocyte maturation arrest; and common findings: Cryptozoospermia and Non-obstructive azoospermia.

Organ System	Phenotype Count	Example Features
Hormones	1	Male infertility

Explore clinical features

Genetic Landscape

TEX15 function has not been fully characterized.

Spermatogenic failure 25 is associated with mutations in the TEX15 gene on chromosome 8.

Diagnosis

Genetic testing for TEX15 is available. Testing is considered confirmatory for diagnosis.

Prognosis

Phenotype severity distribution: 3 always present features, 2 common features.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for spermatogenic failure 25.

7 publications have been identified in PubMed for spermatogenic failure 25. Research spans Epidemiology / Natural History (43%), Review / Meta-Analysis (29%), and Case Report / Case Series (14%).

Recent Publications

Parikesit D (2026). [PMID: 42158581](https://pubmed.ncbi.nlm.nih.gov/42158581/). *F1000Res*. [Epidemiology / Natural History]
Amasdl S (2026). [PMID: 42097595](https://pubmed.ncbi.nlm.nih.gov/42097595/). *Clin Exp Reprod Med*. [Epidemiology / Natural History]
Noor AA (2026). [PMID: 41271156](https://pubmed.ncbi.nlm.nih.gov/41271156/). *Parasitol Int*. [Review / Meta-Analysis]
Kamoshita M (2026). [PMID: 41937972](https://pubmed.ncbi.nlm.nih.gov/41937972/). *Reprod Med Biol*. [Review / Meta-Analysis]
Harmak H (2025). [PMID: 39804284](https://pubmed.ncbi.nlm.nih.gov/39804284/). *Genet Test Mol Biomarkers*. [Case Report / Case Series]

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 7:47 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:617960

GARD

Genetic and Rare Diseases Info Center

GARD:16274

Questions for Your Care Team

→Should my partner and I meet with a genetic counselor to discuss carrier status and family planning?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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spermatogenic failure 25

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

GARD

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Questions for Your Care Team

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