AURKC encodes aurora kinase C (309 aa). Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. Highest expression in Testis (85.3 TPM) and Brain Cerebellar Hemisphere (5.9 TPM).

Spermatogenic failure 5 is caused by mutations in the AURKC gene on chromosome 19.

AURKC is classified as a druggable target (Druggable Genome, Enzyme, Kinase, and Serine Threonine Kinase categories) with score 2.8.

Genetic testing for AURKC is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for spermatogenic failure 5 has been reported in the published literature.

Phenotype severity distribution: 3 always present features.

No clinical trials have been registered for spermatogenic failure 5.

33 publications have been identified in PubMed for spermatogenic failure 5. Research spans Basic Science / Preclinical (45%), Diagnostic / Biomarker (15%), and Review / Meta-Analysis (12%).

Recent Publications

• Zagorac A (2026). [PMID: 41957852](https://pubmed.ncbi.nlm.nih.gov/41957852/). *Mol Cytogenet*. [Diagnostic / Biomarker]

• Ruan J (2026). [PMID: 41596239](https://pubmed.ncbi.nlm.nih.gov/41596239/). *International journal of molecular sciences*. [Clinical Trial Publication]

• Arbabi Dastgerd M (2026). [PMID: 41624734](https://pubmed.ncbi.nlm.nih.gov/41624734/). *Iranian journal of pathology*. [Review / Meta-Analysis]

• Noor AA (2026). [PMID: 41271156](https://pubmed.ncbi.nlm.nih.gov/41271156/). *Parasitology international*. [Basic Science / Preclinical]

• Atkins GR (2026). [PMID: 41756962](https://pubmed.ncbi.nlm.nih.gov/41756962/). *bioRxiv : the preprint server for biology*. [Basic Science / Preclinical]

• Balde-Camara A (2026). [PMID: 41706354](https://pubmed.ncbi.nlm.nih.gov/41706354/). *Journal of assisted reproduction and genetics*. [Basic Science / Preclinical]

• Jeanne F (2026). [PMID: 41724374](https://pubmed.ncbi.nlm.nih.gov/41724374/). *Journal of proteomics*. [Gene Therapy / Novel Therapeutics]

• Caroppo E (2026). [PMID: 40220323](https://pubmed.ncbi.nlm.nih.gov/40220323/). *Andrology*. [Clinical Trial Publication]

• Zhang J (2026). [PMID: 41528256](https://pubmed.ncbi.nlm.nih.gov/41528256/). *Systems biology in reproductive medicine*. [Gene Therapy / Novel Therapeutics]

• Broojeni JV (2026). [PMID: 41932285](https://pubmed.ncbi.nlm.nih.gov/41932285/). *Reprod Biomed Online*. [Review / Meta-Analysis]