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spermatogenic failure, X-linked, 2 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

spermatogenic failure, X-linked, 2

MONDO:0010647

Also known as:TEX11 azoospermiaazoospermia caused by mutation in TEX11spermatogenic failure, X-linked, 2, X-linked recessive

Overview

Any azoospermia in which the cause of the disease is a mutation in the TEX11 gene.

GeneticsX-linked · TEX11 (chr X)

ResearchLimited published research (8 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include always present findings: Male infertility, Spermatogenesis maturation arrest, and Azoospermia; and sometimes findings: Testicular atrophy.

Organ System	Phenotype Count	Example Features
Hormones	1	Male infertility
Muscles

Genetic Landscape

TEX11 function has not been fully characterized.

Spermatogenic failure, X-linked, 2 is associated with mutations in the TEX11 gene on chromosome X.

Diagnosis

Genetic testing for TEX11 is available. Testing is considered confirmatory for diagnosis.

Prognosis

Phenotype severity distribution: 3 always present features.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for spermatogenic failure, X-linked, 2.

8 publications have been identified in PubMed for spermatogenic failure, X-linked, 2. Research spans Review / Meta-Analysis (38%), Basic Science / Preclinical (38%), and Epidemiology / Natural History (25%).

Recent Publications

Yang F (2026). [PMID: 42059593](https://pubmed.ncbi.nlm.nih.gov/42059593/). *Biol Reprod*. [Review / Meta-Analysis]
Tian Y (2026). [PMID: 41751410](https://pubmed.ncbi.nlm.nih.gov/41751410/). *Current issues in molecular biology*. [Basic Science / Preclinical]
Atkins GR (2026). [PMID: 41756962](https://pubmed.ncbi.nlm.nih.gov/41756962/). *bioRxiv : the preprint server for biology*. [Basic Science / Preclinical]
Le Beulze M (2025). [PMID: 41300722](https://pubmed.ncbi.nlm.nih.gov/41300722/). *Genes*. [Basic Science / Preclinical]
Riera-Escamilla A (2025). [PMID: 40896145](https://pubmed.ncbi.nlm.nih.gov/40896145/). *Human reproduction open*. [Review / Meta-Analysis]

Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 11:11 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:309120

GARD

Genetic and Rare Diseases Info Center

GARD:15302

Questions for Your Care Team

→Should female family members consider carrier screening for TEX11?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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spermatogenic failure, X-linked, 2

Overview

Clinical Presentation

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

GARD

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Questions for Your Care Team

Questions for Your Care Team

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