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spontaneous periodic hypothermia - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

spontaneous periodic hypothermia

MONDO:0017577

Also known as:Shapiro syndromeepisodic spontaneous hypothermiaShapiro's syndrome

Overview

Spontaneous periodic hypothermia (SPH) is a neurological disorder characterized by spontaneous periodic hypothermia and hyperhidrosis in the absence of hypothalamic lesions.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for spontaneous periodic hypothermia.

10 publications have been identified in PubMed for spontaneous periodic hypothermia. Research spans Case Report / Case Series (90%) and Other (10%).

Research Type	Count	% of Total
Patient case studies	9	90%

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 4:48 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:29822

GARD

Genetic and Rare Diseases Info Center

GARD:4815

Questions for Your Care Team

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spontaneous periodic hypothermia

Overview

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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