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striate palmoplantar keratoderma - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

striate palmoplantar keratoderma

MONDO:0018865

Also known as:keratosis palmoplantaris striatakeratosis palmoplantaris striata et areatakeratosis palmoplantaris varians of Wachters

Overview

Striate palmoplantar keratoderma is an isolated, focal, hereditary palmoplantar keratoderma characterized by linear hyperkeratosis along the flexor aspect of the fingers and on palms, as well as focal hyperkeratosis of the plantar skin. Patients present with painful thickening of the skin on palms and soles, with occasional fissuring, blistering and hyperhidrosis. Rarely, hyperkeratosis on other areas may be seen (knees, dorsal aspects of the digits). Histopatologically, widened intercellular spaces between keratinocytes are observed.

OnsetCHILDHOOD

ResearchLimited published research (7 articles)

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for striate palmoplantar keratoderma.

7 publications have been identified in PubMed for striate palmoplantar keratoderma. Research spans Case Report / Case Series (43%), Epidemiology / Natural History (29%), and Review / Meta-Analysis (14%).

Recent Publications

Metze D (2026). [PMID: 42029647](https://pubmed.ncbi.nlm.nih.gov/42029647/). *Dermatopathology (Basel)*. [Basic Science / Preclinical]
Wittmer AN (2025). [PMID: 39540442](https://pubmed.ncbi.nlm.nih.gov/39540442/). *International journal of dermatology*. [Epidemiology / Natural History]
Ahmed S (2025). [PMID: 40878888](https://pubmed.ncbi.nlm.nih.gov/40878888/). *The Journal of dermatology*. [Case Report / Case Series]
He L (2025). [PMID: 39503931](https://pubmed.ncbi.nlm.nih.gov/39503931/). *Genes & genomics*. [Case Report / Case Series]
Gram SB (2025). [PMID: 39630431](https://pubmed.ncbi.nlm.nih.gov/39630431/). *JAMA Dermatol*. [Epidemiology / Natural History]

Data assembled from 3 of 12 sources · Last updated Oct 23, 2026, 11:22 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:50942

GARD

Genetic and Rare Diseases Info Center

GARD:15016

Questions for Your Care Team

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striate palmoplantar keratoderma

Overview

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team