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superior limbic keratoconjunctivitis (SLK) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

superior limbic keratoconjunctivitis

MONDO:0019504

Also known as:SLKTheodore's superior limbic keratoconjunctivitisTheodore's syndrome

Overview

A chronic and recurrent eye disease which affects the superior bulbar conjunctiva (the clear layer that covers the eyeball, over the sclera) and tarsal conjunctiva (the clear layer that lines the eyelids), as well as the superior limbic aspect of the cornea (the area above the cornea). It is commonly found in women 20-70 years of age. The signs and symptoms include burning, redness and irritation and tend to develop slowly over a period of 1 to 10 years.Vision usually remains intact. While the underlying cause of SLK remains unknown, it is believed that the condition is secondary to superior bulbar conjunctiva laxity. Factors inducing conjunctiva laxity include thyroid eye disease (usually hyperthyroidism), tight upper eyelids, and prominent globes. A mimicking disorder has been encountered in soft contact lens (SCL) wearers, typically with exposure to thimerosal-preserved solutions. Treatment of SLK may involve the use of various medications, surgery, or a combination of both.

ResearchLimited published research (8 articles)

Diagnosis

Biomarker and diagnostic research for superior limbic keratoconjunctivitis has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for superior limbic keratoconjunctivitis.

9 publications have been identified in PubMed for superior limbic keratoconjunctivitis. Research spans Review / Meta-Analysis (38%), Clinical Trial Publication (25%), and Diagnostic / Biomarker (13%).

Recent Publications

Gurnani B (2026). [PMID: 36512659](https://pubmed.ncbi.nlm.nih.gov/36512659/). *Unknown Journal*. [Epidemiology / Natural History]
Zatarain-Barrón NC (2026). [PMID: 40445593](https://pubmed.ncbi.nlm.nih.gov/40445593/). *Seminars in ophthalmology*. [Review / Meta-Analysis]
Bibak-Bejandi Z (2025). [PMID: 40537957](https://pubmed.ncbi.nlm.nih.gov/40537957/). *Eye & contact lens*. [Review / Meta-Analysis]
Zong Y (2025). [PMID: 41294299](https://pubmed.ncbi.nlm.nih.gov/41294299/). *Translational vision science & technology*. [Diagnostic / Biomarker]
Abbott KS (2025). [PMID: 41144302](https://pubmed.ncbi.nlm.nih.gov/41144302/). *Journal of visualized experiments : JoVE*. [Review / Meta-Analysis]

Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 6:06 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:88633

GARD

Genetic and Rare Diseases Info Center

GARD:10940

Questions for Your Care Team

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superior limbic keratoconjunctivitis

Overview

Diagnosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team