Teebi-Shaltout syndrome is a rare genetic condition that begins in early development. It is marked by a unique set of physical features that include differences in facial shape and structure. People with this condition often have an unusual head shape with a narrow forehead, eyes that are set wider apart (hypertelorism) along with features such as telecanthus (increased distance between the inner corners of the eyes), small earlobes, a broad nasal bridge with an altered tip, and an underdeveloped side of the nose. The mouth may be small or wide and there can be a high or cleft palate, all of which make the syndrome distinct from other conditions. In addition to these facial differences, Teebi-Shaltout syndrome is associated with ectodermal dysplasia. This means that the skin, hair, and teeth might develop differently, leading to problems such as fewer teeth (oligodontia), delayed tooth development, slow growing hair, and reduced sweating.

The symptoms of Teebi-Shaltout syndrome include various facial features like a narrow forehead, widely spaced eyes (hypertelorism), and a broad nasal bridge. Other noticeable signs include a small or wide mouth, high or cleft palate, and underdeveloped parts of the nose. Problems related to ectodermal development may lead to fewer teeth than usual, slow growing hair, and less sweating. Skeletal differences such as permanently bent fingers (camptodactyly) and the presence of a caudal appendage are also part of the syndrome. Short stature and unusual lines on the palms are additional observations.

Teebi-Shaltout syndrome is a genetic condition that results from developmental defects occurring during embryogenesis. While it is known to be inherited genetically, specific gene changes leading to this condition have not been detailed in the available information. Thus, details on exact genetic causes and risk factors remain limited.