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A distinct marginal thinning of the cornea which causes high degree of against-the-rule astigmatism
Biomarker and diagnostic research for Terrien marginal degeneration has been reported in the published literature.
No clinical trials have been registered for Terrien marginal degeneration.
7 publications have been identified in PubMed for Terrien marginal degeneration. Research spans Epidemiology / Natural History (43%), Review / Meta-Analysis (29%), and Diagnostic / Biomarker (14%).
Krakhmaleva DA (2026). [PMID: 42048102](https://pubmed.ncbi.nlm.nih.gov/42048102/). *Vestn Oftalmol*. [Review / Meta-Analysis]
Ahn J (2026). [PMID: 42140270](https://pubmed.ncbi.nlm.nih.gov/42140270/). *J Am Vet Med Assoc*. [Epidemiology / Natural History]
Ruutila M (2026). [PMID: 40387305](https://pubmed.ncbi.nlm.nih.gov/40387305/). *Acta Ophthalmol*. [Epidemiology / Natural History]
Roig-Ferreruela G (2025). [PMID: 39993559](https://pubmed.ncbi.nlm.nih.gov/39993559/). *Arch Soc Esp Oftalmol (Engl Ed)*. [Review / Meta-Analysis]
Sharma V (2025). [PMID: 41174237](https://pubmed.ncbi.nlm.nih.gov/41174237/). *Eye (Lond)*. [Case Report / Case Series]
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 2:52 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about Terrien marginal degeneration
Ruutila M (2024). [PMID: 39383475](https://pubmed.ncbi.nlm.nih.gov/39383475/). *Cornea*. [Epidemiology / Natural History]
AI-curated news mentioning Terrien marginal degeneration
Updated May 15, 2026
A study reveals that central corneal degeneration syndrome in dogs exhibits clinical characteristics and disease progression similar to Terrien marginal degeneration in humans. This finding may enhance understanding of the disease in both species.