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thrombophilia, familial, due to decreased release of tissue plasminogen activator (THPH9) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

thrombophilia, familial, due to decreased release of tissue plasminogen activator

MONDO:0012872

Also known as:THPH9hyperfibrinolysis, familial, due to increased release of platthrombophilia, familial, due to decreased release of PLAT

Overview

GeneticsAutosomal dominant

Patient Orgs1 organizations · Plasminogen Deficiency Foundation

ResearchLimited published research (3 articles)

Clinical Presentation

Features include: Recurrent deep vein thrombosis.

Explore clinical features

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for thrombophilia, familial, due to decreased release of tissue plasminogen activator.

3 publications have been identified in PubMed for thrombophilia, familial, due to decreased release of tissue plasminogen activator. Research spans Review / Meta-Analysis (33%), Case Report / Case Series (33%), and Epidemiology / Natural History (33%).

Recent Publications

Hussein A (2025). [PMID: 40302365](https://pubmed.ncbi.nlm.nih.gov/40302365/). *Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis*. [Review / Meta-Analysis]
Ivanova N (2025). [PMID: 40981125](https://pubmed.ncbi.nlm.nih.gov/40981125/). *Reports (MDPI)*. [Case Report / Case Series]
Abdelsamei EM (2024). [PMID: 39349608](https://pubmed.ncbi.nlm.nih.gov/39349608/). *Annals of hematology*. [Epidemiology / Natural History]

Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 11:35 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Patient Support

Patient Advocacy Groups

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Plasminogen Deficiency FoundationPrimary Focus

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Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:612348

Questions for Your Care Team

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thrombophilia, familial, due to decreased release of tissue plasminogen activator

Overview

Clinical Presentation

Explore clinical features

Research Landscape

Recent Publications

Patient Support

Patient Advocacy Groups

Medical References

External Resources

OMIM

Related Diseases

Questions for Your Care Team

Questions for Your Care Team