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A differentiated adenocarcinoma arising from the follicular cells of the thyroid gland. Radiation exposure is a risk factor and it is the most common malignant thyroid lesion, comprising 75% to 80% of all thyroid cancers in iodine sufficient countries. Diagnostic procedures include thyroid ultrasound and fine needle biopsy. Microscopically, the diagnosis is based on the distinct characteristics of the malignant cells, which include enlargement, oval shape, elongation, and overlapping of the nuclei. The nuclei also display clearing or have a ground glass appearance.
58 clinical trials registered, 20 recruiting. Interventions under study include other interventions, procedural interventions, drug therapy, and medical devices. Pipeline includes 1 PHASE4, 3 PHASE3, 13 PHASE2. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06592755](https://clinicaltrials.gov/study/NCT06592755) |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 4:31 PM UTC
Single-Incision Gasless Endoscopic Total Thyroidectomy Via Subclavian Approach Versus Open Surgery for PTC |
— |
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University |
RECRUITING |
[NCT05766098](https://clinicaltrials.gov/study/NCT05766098) | Definition of Mutational Profile of Papillary Thyroid Tumors by Mass-ARRAY | — | Istituto Auxologico Italiano | RECRUITING |
[NCT06082180](https://clinicaltrials.gov/study/NCT06082180) | A Prospective, Open-label, Multicenter, Randomized Controlled Phase III Study of Prophylactic Central Neck Dissection in Low-risk Papillary Thyroid Cancer | PHASE3 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | RECRUITING |
[NCT06286631](https://clinicaltrials.gov/study/NCT06286631) | Prediction of Lymph Node Metastasis in Patients With Thyroid Malignancy by a New Scale | — | Second Affiliated Hospital of Xi'an Jiaotong University | RECRUITING |
[NCT06133374](https://clinicaltrials.gov/study/NCT06133374) | Concordance of Molecular Classification Based on Fine Needle Biopsy (FNB) and Surgical Samples | — | University of Calgary | RECRUITING |
5 publications have been identified in PubMed for thyroid gland papillary carcinoma. Research spans Case Report / Case Series (80%) and Epidemiology / Natural History (20%).
Jacob A (2025). [PMID: 40636652](https://pubmed.ncbi.nlm.nih.gov/40636652/). *Cureus*. [Case Report / Case Series]
Yunatanov A (2025). [PMID: 41450425](https://pubmed.ncbi.nlm.nih.gov/41450425/). *Cureus*. [Case Report / Case Series]
Balaji AN (2025). [PMID: 40125144](https://pubmed.ncbi.nlm.nih.gov/40125144/). *Cureus*. [Case Report / Case Series]
Al-Haideri MH (2024). [PMID: 39087148](https://pubmed.ncbi.nlm.nih.gov/39087148/). *Cureus*. [Epidemiology / Natural History]
Sierra Castillo S (2024). [PMID: 39553134](https://pubmed.ncbi.nlm.nih.gov/39553134/). *Cureus*. [Case Report / Case Series]
AI-curated news mentioning thyroid gland papillary carcinoma
Updated Aug 29, 2026
A new study highlights the diffuse sclerosing variant of papillary thyroid carcinoma as a rare and invasive cancer in childhood. This research underscores the challenges in diagnosing and treating this specific cancer variant.
Recent research highlights the impact of TERT promoter variants and older age on the prognosis of papillary thyroid carcinoma. This study provides insights that could influence future treatment strategies and patient management.
A recent study indicates that incidentally detected papillary thyroid carcinoma does not negatively affect pregnancy outcomes during fertility treatment. This finding may influence clinical practices regarding the management of thyroid cancer in women seeking fertility assistance.