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Thyrotoxic periodic paralysis (TPP) is a rare neurological disease characterized by recurrent episodes of paralysis and hypokalemia during a thyrotoxic state.
Biomarker and diagnostic research for thyrotoxic periodic paralysis has been reported in the published literature.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for thyrotoxic periodic paralysis.
55 publications have been identified in PubMed for thyrotoxic periodic paralysis. Research spans Case Report / Case Series (75%), Epidemiology / Natural History (9%), and Other (7%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 41 | 75% |
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 3:56 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
5 |
9% |
Other research | 4 | 7% |
Research summaries | 2 | 4% |
Laboratory research | 2 | 4% |
Testing and diagnosis research | 1 | 2% |
Advani A (2026). [PMID: 41616965](https://pubmed.ncbi.nlm.nih.gov/41616965/). *Clinical biochemistry*. [Case Report / Case Series]
Siddamreddy S (2026). [PMID: 32809505](https://pubmed.ncbi.nlm.nih.gov/32809505/). *Unknown Journal*. [Other]
Unknown (2026). [PMID: 40839546](https://pubmed.ncbi.nlm.nih.gov/40839546/). *Hormone research in paediatrics*. [Case Report / Case Series]
Balderrama D (2026). [PMID: 42005221](https://pubmed.ncbi.nlm.nih.gov/42005221/). *Cureus*. [Case Report / Case Series]
Saeed FY (2026). [PMID: 41938294](https://pubmed.ncbi.nlm.nih.gov/41938294/). *AACE Endocrinol Diabetes*. [Case Report / Case Series]
Bayrak Demirel O (2026). [PMID: 39719130](https://pubmed.ncbi.nlm.nih.gov/39719130/). *Hormone research in paediatrics*. [Case Report / Case Series]
Ottu Para NK (2026). [PMID: 42099363](https://pubmed.ncbi.nlm.nih.gov/42099363/). *Cureus*. [Case Report / Case Series]
Kostopoulos G (2026). [PMID: 41823424](https://pubmed.ncbi.nlm.nih.gov/41823424/). *The Journal of clinical endocrinology and metabolism*. [Case Report / Case Series]
Vincent AA (2026). [PMID: 41883915](https://pubmed.ncbi.nlm.nih.gov/41883915/). *Cureus*. [Case Report / Case Series]
White JA (2026). [PMID: 41960015](https://pubmed.ncbi.nlm.nih.gov/41960015/). *Cureus*. [Case Report / Case Series]
AI-curated news mentioning thyrotoxic periodic paralysis
Updated Jul 16, 2026
A recent study highlights thyrotoxic periodic paralysis as a rare variant of Graves' disease, presenting with transient ventricular arrhythmia. This discovery may enhance understanding of the cardiovascular implications in patients with hyperthyroidism.