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tooth agenesis, selective, 8 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

tooth agenesis, selective, 8

MONDO:0014901

Also known as:STHAG8WNT10B tooth agenesistooth agenesis caused by mutation in WNT10B

Overview

Any tooth agenesis in which the cause of the disease is a mutation in the WNT10B gene.

GeneticsAutosomal dominant · WNT10B (chr 12)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include always present findings: Microdontia, Selective tooth agenesis, and Sparse eyebrow; and common findings: Dry skin and Sparse hair.

Organ System	Phenotype Count	Example Features
Skin	1	Dry skin

Explore clinical features

Genetic Landscape

WNT10B function has not been fully characterized.

Tooth agenesis, selective, 8 is associated with mutations in the WNT10B gene on chromosome 12.

Diagnosis

Genetic testing for WNT10B is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for tooth agenesis, selective, 8 has been reported in the published literature.

Prognosis

Phenotype severity distribution: 3 always present features, 2 common features.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for tooth agenesis, selective, 8.

15 publications have been identified in PubMed for tooth agenesis, selective, 8. Research spans Review / Meta-Analysis (27%), Epidemiology / Natural History (27%), and Other (13%).

Research Type	Count	% of Total
Research summaries	4	27%

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 1:00 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:617073

GARD

Genetic and Rare Diseases Info Center

GARD:18250

Questions for Your Care Team

→Should I pursue genetic testing for WNT10B, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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tooth agenesis, selective, 8

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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