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Biomarker and diagnostic research for total spina bifida aperta has been reported in the published literature.
No clinical trials have been registered for total spina bifida aperta.
8 publications have been identified in PubMed for total spina bifida aperta. Research spans Basic Science / Preclinical (25%), Epidemiology / Natural History (25%), and Diagnostic / Biomarker (13%).
Kumar M (2026). [PMID: 40239713](https://pubmed.ncbi.nlm.nih.gov/40239713/). *Am J Perinatol*. [Diagnostic / Biomarker]
Dhombres F (2025). [PMID: 40629359](https://pubmed.ncbi.nlm.nih.gov/40629359/). *Orphanet J Rare Dis*. [Review / Meta-Analysis]
Müller JM (2025). [PMID: 38471477](https://pubmed.ncbi.nlm.nih.gov/38471477/). *Fetal Diagn Ther*. [Basic Science / Preclinical]
Yang L (2025). [PMID: 40279995](https://pubmed.ncbi.nlm.nih.gov/40279995/). *Int J Surg Case Rep*. [Case Report / Case Series]
Brawura Biskupski Samaha R (2025). [PMID: 41301720](https://pubmed.ncbi.nlm.nih.gov/41301720/). *Biomedicines*. [Clinical Trial Publication]
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 3:02 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Pontiggia L (2024). [PMID: 38697275](https://pubmed.ncbi.nlm.nih.gov/38697275/). *Exp Cell Res*. [Basic Science / Preclinical]
Volpe N (2024). [PMID: 39074608](https://pubmed.ncbi.nlm.nih.gov/39074608/). *Am J Obstet Gynecol MFM*. [Epidemiology / Natural History]