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transient hypogammaglobulinemia of infancy (THI) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

transient hypogammaglobulinemia of infancy

MONDO:0015698

Also known as:THI

Overview

A rare, primary humoral immunodeficiency of childhood characterized by decreasing serum levels of immunoglobulin G (IgG) as maternal antibodies clear the circulation while serum levels of immunoglobulin A and immunoglobulin M remain normal or are slightly decreased. Diagnosis may be suspected after the age of six months when a child's own synthesis of IgG should accelerate but it must be confirmed retrospectively after normalization of all serum immunoglobulin levels is seen by ages 2-6. This disorder may be caused by inadequate activation of progenitor B cells, defective class-switching or may even represent a maturational variant. Typically, a normal response to protein antigens is found while there is a notably diminished response to viral and bacterial polysaccharide antigens. Clinical presentation may include recurrent infections especially those of the respiratory tract. Despite increased susceptibility to infection in childhood, this disorder is self-limited with minimal implications for a normal life span.

Diagnosis

Biomarker and diagnostic research for transient hypogammaglobulinemia of infancy has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for transient hypogammaglobulinemia of infancy.

10 publications have been identified in PubMed for transient hypogammaglobulinemia of infancy. Research spans Review / Meta-Analysis (40%), Epidemiology / Natural History (30%), and Diagnostic / Biomarker (10%).

Research Type	Count	% of Total
Research summaries	4	40%

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 5:40 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:169139

GARD

Genetic and Rare Diseases Info Center

GARD:20112

Questions for Your Care Team

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transient hypogammaglobulinemia of infancy

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications