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tropical pancreatitis (TCP) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

tropical pancreatitis

MONDO:0011986

Also known as:TCPtropical calcific chronic pancreatitisfibrocalculous pancreatic diabetes, susceptibility to

Overview

Tropical pancreatitis is a rare pancreatic disease of juvenile onset occurring mainly in tropical developing countries and characterized by chronic non-alcoholic pancreatitis manifesting with abdominal pain, steatorrhea and fibrocalculous pancreatopathy. It is also commonly associated with the development of pancreatic calculi and pancreatic cancer at a much higher frequency than seen in ordinary chronic pancreatitis.

GeneticsAutosomal recessive, Autosomal dominant · SPINK1 (chr 5)

ResearchLimited published research (5 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include always present findings: Pancreatic calcification. 5 total HPO annotations.

Organ System	Phenotype Count	Example Features
Digestive system	3	Chronic pancreatitis, Pancreatic calcification, Abdominal pain
Hormones

Genetic Landscape

SPINK1 function has not been fully characterized.

Tropical pancreatitis is associated with mutations in the SPINK1 gene on chromosome 5.

Diagnosis

Genetic testing for SPINK1 is available. Testing is considered confirmatory for diagnosis.

Prognosis

Phenotype severity distribution: 1 always present feature.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for tropical pancreatitis.

5 publications have been identified in PubMed for tropical pancreatitis. Research spans Review / Meta-Analysis (40%), Case Report / Case Series (20%), and Basic Science / Preclinical (20%).

Recent Publications

Nahid KL (2026). [PMID: 41474905](https://pubmed.ncbi.nlm.nih.gov/41474905/). *Mymensingh medical journal : MMJ*. [Epidemiology / Natural History]
Shah IA (2026). [PMID: 41514216](https://pubmed.ncbi.nlm.nih.gov/41514216/). *BMC gastroenterology*. [Review / Meta-Analysis]
Rajendran T (2025). [PMID: 39611599](https://pubmed.ncbi.nlm.nih.gov/39611599/). *Journal of minimal access surgery*. [Review / Meta-Analysis]
Shrivastava A (2025). [PMID: 38500246](https://pubmed.ncbi.nlm.nih.gov/38500246/). *Journal of biomolecular structure & dynamics*. [Basic Science / Preclinical]
Ramala SR (2024). [PMID: 38854193](https://pubmed.ncbi.nlm.nih.gov/38854193/). *Cureus*. [Case Report / Case Series]

Data assembled from 6 of 12 sources · Last updated Sep 18, 2026, 2:20 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:608189

Orphanet

European rare disease database

Orphanet:103918

GARD

Genetic and Rare Diseases Info Center

GARD:16946

Questions for Your Care Team

→Should my partner and I meet with a genetic counselor to discuss carrier status and family planning?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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tropical pancreatitis

Overview

Clinical Presentation

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

Orphanet

GARD

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Questions for Your Care Team

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