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Undifferentiated carcinoma of the corpus uteri is a rare cancer of corpus uteri presenting as a large, polypoid, intraluminal mass with necrosis, composed of small to intermediate-size, relatively uniform, dyshesive cells displaying no differentiation. It usually presents with dysfunctional bleeding or vaginal discharge and, less often, abdominal pain. Association with Lynch syndrome was reported.
Biomarker and diagnostic research for undifferentiated carcinoma of the corpus uteri has been reported in the published literature.
6 clinical trials registered, 2 recruiting. Interventions under study include drug therapy, procedural interventions, other interventions, and biologic therapy. Pipeline includes 2 PHASE3, 3 PHASE2, 1 PHASE1. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT05112601](https://clinicaltrials.gov/study/NCT05112601) |
Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 8:34 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinoma |
PHASE2 |
National Cancer Institute (NCI) |
RECRUITING |
[NCT03914612](https://clinicaltrials.gov/study/NCT03914612) | Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) in Stage III-IV or Recurrent Endometrial Cancer | PHASE3 | National Cancer Institute (NCI) | ACTIVE_NOT_RECRUITING |
[NCT03660826](https://clinicaltrials.gov/study/NCT03660826) | Testing the Combination of Olaparib and Durvalumab, Cediranib and Durvalumab, Olaparib and Capivasertib, and Cediranib Alone in Recurrent or Refractory Endometrial Cancer Following the Earlier Phase of the Study That Tested Olaparib and Cediranib in Comparison to Cediranib Alone, and Olaparib Alone | PHASE2 | National Cancer Institute (NCI) | ACTIVE_NOT_RECRUITING |
[NCT05256225](https://clinicaltrials.gov/study/NCT05256225) | Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma | PHASE3 | National Cancer Institute (NCI) | RECRUITING |
[NCT04719273](https://clinicaltrials.gov/study/NCT04719273) | Onapristone and Anastrozole for the Treatment of Refractory Hormone Receptor Positive Endometrial Cancer | PHASE2 | Thomas Jefferson University | UNKNOWN |
50 publications have been identified in PubMed for undifferentiated carcinoma of the corpus uteri. Research spans Case Report / Case Series (36%), Diagnostic / Biomarker (20%), and Review / Meta-Analysis (14%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 18 | 36% |
Testing and diagnosis research | 10 | 20% |
Research summaries | 7 | 14% |
Disease patterns and progression | 5 | 10% |
New treatment approaches | 4 | 8% |
Laboratory research | 3 | 6% |
Clinical study results | 2 | 4% |
Other research | 1 | 2% |
Hao C (2026). [PMID: 41987392](https://pubmed.ncbi.nlm.nih.gov/41987392/). *Cancer Med*. [Basic Science / Preclinical]
Özmaskan F (2026). [PMID: 41773223](https://pubmed.ncbi.nlm.nih.gov/41773223/). *Int J Womens Health*. [Epidemiology / Natural History]
Li Y (2026). [PMID: 40590445](https://pubmed.ncbi.nlm.nih.gov/40590445/). *Int J Gynaecol Obstet*. [Review / Meta-Analysis]
Frerichs HD (2026). [PMID: 42145191](https://pubmed.ncbi.nlm.nih.gov/42145191/). *J Obstet Gynaecol*. [Case Report / Case Series]
Forooshani M (2026). [PMID: 40791068](https://pubmed.ncbi.nlm.nih.gov/40791068/). *Int J Surg Pathol*. [Case Report / Case Series]
An Y (2026). [PMID: 41899267](https://pubmed.ncbi.nlm.nih.gov/41899267/). *J Clin Med*. [Case Report / Case Series]
Sapienza LG (2026). [PMID: 40972906](https://pubmed.ncbi.nlm.nih.gov/40972906/). *Int J Radiat Oncol Biol Phys*. [Review / Meta-Analysis]
Baydemir ŞK (2026). [PMID: 41493029](https://pubmed.ncbi.nlm.nih.gov/41493029/). *J Obstet Gynaecol Res*. [Epidemiology / Natural History]
Habermann EB (2026). [PMID: 41562441](https://pubmed.ncbi.nlm.nih.gov/41562441/). *J Am Coll Surg*. [Epidemiology / Natural History]
Serarslan A (2026). [PMID: 41836232](https://pubmed.ncbi.nlm.nih.gov/41836232/). *Front Oncol*. [Epidemiology / Natural History]