Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy
A cardiac conduction disorder characterized by an electrocardiographic finding of ventricular pre-excitation, which is a short PR interval and a long QRS interval with a delta wave. Most individuals are asymptomatic; however they can experience periods of palpitations, shortness of breath or syncope during tachycardic episodes.
Features include always present findings: Wolff-Parkinson-White syndrome and Ventricular preexcitation; and common findings: Atrial flutter, Paroxysmal atrial fibrillation, and Syncope. 10 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Heart and blood vessels | 5 | Ventricular preexcitation with multiple accessory pathways, Ventricular preexcitation, Atrial flutter |
Brain and nerves | 1 | Wolff-Parkinson-White syndrome |
PRKAG2 function has not been fully characterized.
Wolff-Parkinson-White syndrome is associated with mutations in the PRKAG2 gene on chromosome 7.
Genetic testing for PRKAG2 is available. Testing is considered confirmatory for diagnosis.
Biomarker and diagnostic research for Wolff-Parkinson-White syndrome has been reported in the published literature.
Phenotype severity distribution: 2 always present features, 3 common features.
2 clinical trials registered. Interventions under study include drug therapy and procedural interventions. Pipeline includes 1 PHASE1. Research is sponsored by a mix of industry and academic institutions.
172 publications have been identified in PubMed for Wolff-Parkinson-White syndrome. Research spans Case Report / Case Series (48%), Review / Meta-Analysis (13%), and Epidemiology / Natural History (10%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 82 | 48% |
Research summaries | 22 | 13% |
Disease patterns and progression | 17 | 10% |
Testing and diagnosis research | 16 | 9% |
Clinical study results | 14 | 8% |
Laboratory research | 12 | 7% |
Other research | 8 | 5% |
New treatment approaches | 1 | 1% |
Nguyen R (2026). [PMID: 42255796](https://pubmed.ncbi.nlm.nih.gov/42255796/). *Cureus*. [Case Report / Case Series]
Zhan ZQ (2026). [PMID: 40967987](https://pubmed.ncbi.nlm.nih.gov/40967987/). *J Electrocardiol*. [Other]
Zhou X (2026). [PMID: 41211630](https://pubmed.ncbi.nlm.nih.gov/41211630/). *Pacing Clin Electrophysiol*. [Case Report / Case Series]
Yi S (2026). [PMID: 41348084](https://pubmed.ncbi.nlm.nih.gov/41348084/). *JACC Case Rep*. [Case Report / Case Series]
Kosing JM (2026). [PMID: 42072348](https://pubmed.ncbi.nlm.nih.gov/42072348/). *Biomedicines*. [Diagnostic / Biomarker]
Chang S (2026). [PMID: 41553922](https://pubmed.ncbi.nlm.nih.gov/41553922/). *Pacing Clin Electrophysiol*. [Review / Meta-Analysis]
Richard S (2026). [PMID: 42110064](https://pubmed.ncbi.nlm.nih.gov/42110064/). *Cureus*. [Case Report / Case Series]
Abrahim M (2026). [PMID: 41997841](https://pubmed.ncbi.nlm.nih.gov/41997841/). *J Sci Med Sport*. [Case Report / Case Series]
McIlraith B (2026). [PMID: 41695518](https://pubmed.ncbi.nlm.nih.gov/41695518/). *Heart Rhythm O2*. [Case Report / Case Series]
Bharati A (2026). [PMID: 41860500](https://pubmed.ncbi.nlm.nih.gov/41860500/). *JACC Clin Electrophysiol*. [Case Report / Case Series]
Data assembled from 7 of 12 sources · Last updated Sep 19, 2026, 5:51 PM UTC
Patient Advocacy Groups (PAGs) provide support, resources, and community for patients and caregivers.
Online Mendelian Inheritance in Man
European rare disease database
Common questions about Wolff-Parkinson-White syndrome
AI-curated news mentioning Wolff-Parkinson-White syndrome
Updated Jun 2, 2026
A new study explores the use of open-window mapping strategy for treating Wolff-Parkinson-White syndrome in a patient with dextrocardia and situs inversus. This research could enhance understanding of complex arrhythmias in patients with anatomical variations.