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yolk sac tumor - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

yolk sac tumor

MONDO:0005744

Also known as:endodermal sinus neoplasmendodermal sinus tumorendodermal sinus tumour

Find Clinical TrialsTrials

Overview

A non-seminomatous malignant germ cell tumor composed of primitive germ cells. It is the most common malignant germ cell tumor in the pediatric population. It occurs in the infant testis, ovary, sacrococcygeal region, vagina, uterus, prostate, abdomen, liver, retroperitoneum, thorax, and pineal/third ventricle. The tumor mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). Treatment includes: surgical resection, radiation, and chemotherapy. This tumor is very responsive to chemotherapy regimens that include cisplatinum.

Clinical Trials12 registered · 7 recruiting

Diagnosis

Biomarker and diagnostic research for yolk sac tumor has been reported in the published literature.

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

12 clinical trials registered, 7 recruiting. Interventions under study include drug therapy, gene therapy, procedural interventions, and biologic therapy. Pipeline includes 2 PHASE3, 2 PHASE2, 7 PHASE1. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT04684368](https://clinicaltrials.gov/study/NCT04684368)

Data assembled from 4 of 12 sources · Last updated Nov 4, 2026, 5:17 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:876

GARD

Genetic and Rare Diseases Info Center

GARD:348

Questions for Your Care Team

→Are any of the 12 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Research Type	Count	% of Total
Patient case studies	68	46%
Laboratory research	26	18%
Research summaries	17	11%
Disease patterns and progression	17	11%
Other research	9	6%
Testing and diagnosis research	6	4%
Clinical study results	3	2%
New treatment approaches	2	1%

Kisho

yolk sac tumor

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Somatic carcinomas with yolk sac tumor differentiation in the female genital tract: clinicopathological and molecular analysis of four cases with a literature review.

yolk sac tumor

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Somatic carcinomas with yolk sac tumor differentiation in the female genital tract: clinicopathological and molecular analysis of four cases with a literature review.