a case of percutaneous closure of a complex coronary artery fistula

Original title: “[A case of percutaneous closure of a complex coronary artery fistula].”

acute perimyocarditis complicated by giant wall pseudoaneurysm

Original title: “[Acute perimyocarditis complicated by giant wall pseudoaneurysm].”

case report of an unusual cecal metastasis of a primary cervical squamous cell carcinoma

Original title: “Case report of an unusual cecal metastasis of a primary cervical squamous cell carcinoma.”

retroperitoneal schwannoma mimicking a large adnexal mass during pregnancy a case report of full term delivery followed by postpartum surgical management

Original title: “Retroperitoneal schwannoma mimicking a large adnexal mass during pregnancy: A case report of full-term delivery followed by postpartum surgical management.”

uterine lithiasis triggered by an intrauterine contraceptive device a case report and literature review

Original title: “Uterine lithiasis triggered by an intrauterine contraceptive device: A case report and literature review.”

Multidisciplinary experts rethink advanced cutaneous squamous cell carcinoma care, weighing immunotherapy options, trial data limits, adverse events, and smoother dermatology-oncology referrals. Multidisciplinary experts rethink advanced cutaneous squamous cell carcinoma care, weighing immunotherapy options, trial data limits, adverse events, and smoother dermatology-oncology referrals. ... Cutaneous squamous cell carcinoma (cSCC) is usually treated with surgery or radiation, but when the disease advances beyond curative-intent treatment, management stops being a single specialty’s decision. High-risk features including nodal disease, poor differentiation, and extensive perineural invasion drive the view that surgery plus adjuvant radiation is insufficient and systemic therapy should be considered. Neoadjuvant immunotherapy to downstage locally advanced cSCC remains underutilized in dermatology workflows despite perceived clinical rationale in aggressive presentations. Pivotal trials show broadly comparable durability across PD-1/PD-L1 inhibitors, with ORRs ~45%–55% in locally advanced disease and variable metastatic activity by study and schedule. All 3 groups reviewed a case of a 72-year-old man with locally advanced, node-positive disease and examined how systemic immunotherapy options are reshaping referral and treatment decisions. Rather than focusing on individual presentations, discussions centered on shared clinical challenges: comparing trial data across 3 approved checkpoint inhibitors, reading cross-trial comparisons with appropriate caution, managing immune-related adverse events, and bridging referral gaps between dermatology and oncology. Cross-trial efficacy ranking is unreliable due to major baseline imbalances, particularly prior systemic therapy exposure, which was far lower in cosibelimab cohorts than pembrolizumab and some cemiplimab arms. Treatment goals can diverge, with some prioritizing complete response in metastatic disease while others value partial response or stable disease aligned with patient-centric symptom and control objectives.SHOW MORE

Original title: “Reshaping Advanced Cutaneous Squamous Cell Carcinoma Management Beyond Surgery | Dermatology Times”

exome analysis of 22 319 individuals links extremely rare copy number variants and 22q11 21 dosage to alzheimer risk

Original title: “Exome analysis of 22,319 individuals links extremely rare copy-number variants and 22q11.21 dosage to Alzheimer risk.”

lighting up biology gfp inspired fluorescent probes for sensing and imaging

Original title: “Lighting Up Biology: GFP-Inspired Fluorescent Probes for Sensing and Imaging.”

secondary hemophagocytic lymphohistiocytosis in an immunocompetent adult a case report distinguishing sarcoidosis from histoplasmosis

Original title: “Secondary Hemophagocytic lymphohistiocytosis in an immunocompetent adult: a case report distinguishing sarcoidosis from histoplasmosis.”

reprogramming translation for rare disease therapy challenges posed by large genes

Original title: “Reprogramming translation for rare disease therapy: challenges posed by large genes.”

autoimmune disease patients with comorbid cancer exhibit prominent immunometabolic crosstalk

Original title: “Autoimmune disease patients with comorbid cancer exhibit prominent immunometabolic crosstalk.”

global downstream bmp15 pathway analysis in human ovarian granulosa cells reveals novel genetic variations associated with primary ovarian insufficiency

Original title: “Global downstream BMP15 pathway analysis in human ovarian granulosa cells reveals novel genetic variations associated with primary ovarian insufficiency.”

mild form of aromatic l amino acid decarboxylase deficiency

Original title: “Mild form of aromatic L-amino acid decarboxylase deficiency.”

maturational trajectories of neurophysiological indices of inhibitory control in typically developing children

Original title: “Maturational trajectories of neurophysiological indices of inhibitory control in typically developing children.”

propensity score integrated win ratio method for placebo borrowing

Original title: “A propensity score-integrated win ratio method for placebo borrowing.”

spontaneous splenic rupture and uterine serosal bleeding at 26 weeks in col3a1 related vascular ehlers danlos syndrome

Original title: “Spontaneous Splenic Rupture and Uterine Serosal Bleeding at 26 Weeks in COL3A1-Related Vascular Ehlers-Danlos Syndrome.”

ern reconnet slicc sleuro consensus on the therapeutic management of rare systemic lupus erythematosus manifestations part 2

Original title: “ERN ReCONNET-SLICC-SLEuro consensus on the therapeutic management of rare systemic lupus erythematosus manifestations (part 2).”

mantle cell lymphoma presenting as bullous pemphigoid a rare paraneoplastic syndrome

Original title: “Mantle cell lymphoma presenting as bullous pemphigoid: a rare paraneoplastic syndrome.”

retrieval strategies for embolized left atrial appendage closure devices

Original title: “Retrieval Strategies for Embolized Left Atrial Appendage Closure Devices.”