adolescent dysmenorrhea revealing herlyn werner wunderlich syndrome with endometriosis a radiologic case report

Original title: “Adolescent dysmenorrhea revealing Herlyn-Werner-Wunderlich syndrome with endometriosis: A radiologic case report.”

68ga fapi 04 pet ct findings in primary hyperoxaluria type 1

Original title: “68Ga-FAPI-04 PET/CT Findings in Primary Hyperoxaluria Type 1.”

liver associated findings and outcomes in a telomere biology disorders clinic

Original title: “Liver-associated findings and outcomes in a telomere biology disorders clinic.”

sigmoid colon perforation following a self administered cleansing enema a case report

Original title: “Sigmoid colon perforation following a self-administered cleansing enema: a case report.”

proteo metabolomic profiling of pmm2 cdg reveals dysregulation of retinoic acid synthesis myo inositol and the hexosamine pathway

Original title: “Proteo-Metabolomic Profiling of PMM2-CDG Reveals Dysregulation of Retinoic Acid Synthesis, Myo-Inositol, and the Hexosamine Pathway.”

The findings position their drug, zipalertinib, as a threat to multiple approved medicines — while setting a bar for others in testing.

Original title: “New Taiho, Cullian data heats up lung cancer drug battle”

A drug can look brilliant in a single-arm study and fail completely once placed head-to-head against an active control. That gap between apparent effect and real effect is the entire reason controlled clinical trials exist. Most participants improve for reasons that have nothing to do with ... A drug can look brilliant in a single-arm study and fail completely once placed head-to-head against an active control. That gap between apparent effect and real effect is the entire reason controlled clinical trials exist. Most participants improve for reasons that have nothing to do with the investigational product. Learn how controlled clinical trials work: control types, blinding, comparator drug sourcing, and the supply chain decisions that determine study feasibility. Comparing the two groups reveals what the treatment actually does. A controlled trial has a comparison group. A randomized controlled trial assigns participants to groups by chance. Randomization is what removes allocation bias, so an RCT is a stronger form of controlled trial. No. Early exploratory studies and some rare disease or oncology trials are single-arm. Most participants improve for reasons that have nothing to do with the investigational product. Disease states fluctuate. Trial participants often receive more rigorous routine care. Without a control group, clinical noise cannot be separated from genuine treatment benefits.

Original title: “Understanding Controlled Clinical Trials: Design, Comparators and the Supply Chain Behind the Data”

antidepressant use during pregnancy and birth outcomes analysis from the uk norway and sweden

Original title: “Antidepressant Use During Pregnancy and Birth Outcomes: Analysis From the UK, Norway, and Sweden.”

guanabenz in vanishing white matter towards mechanism based disease modification

Original title: “Guanabenz in vanishing white matter: towards mechanism-based disease modification.”

management of incidentally discovered appendiceal malignancies when to perform right hemicolectomy case series and literature review

Original title: “Management of Incidentally Discovered Appendiceal Malignancies: When to Perform Right Hemicolectomy - Case Series and Literature Review.”

case report of primary hyperoxaluria type 1 diagnosed in a geriatric patient receiving dialysis unique clinical course with lumasiran

Original title: “A Case Report of Primary Hyperoxaluria Type 1 Diagnosed in a Geriatric Patient Receiving Dialysis: Unique Clinical Course With Lumasiran.”

cardiac debut myocarditis revealing seronegative primary sj gren s syndrome in a young woman a case report

Original title: “A cardiac debut: Myocarditis revealing seronegative primary Sjögren's syndrome in a young woman-A case report.”

incidentally detected papillary thyroid carcinoma does not impair pregnancy outcomes during fertility treatment

Original title: “Incidentally detected papillary thyroid carcinoma does not impair pregnancy outcomes during fertility treatment.”