Chimeric antigen receptor (CAR)-T cell therapy, which reprograms an individual's immune cells to seek out and destroy certain cancer cells, has revolutionized treatment for blood cancers such as lymphoma. Chimeric antigen receptor (CAR)-T cell therapy, which reprograms an individual's immune cells to seek out and destroy certain cancer cells, has revolutionized treatment for blood cancers such as lymphoma. But in some patients, the treatment can cause serious side effects. New research led by investigators at the Mass General Brigham Cancer Institute, the Broad Institute of MIT and Harvard, and Dana-Farber Cancer Institute has shown that patients' inherited genetic makeup can influence whether they benefit from CAR-T cell therapy or experience toxicity from the treatment. These findings have important implications for understanding how CAR-T cells behave in patients since each CAR-T cell product is unique to the person from whom it is manufactured, unlike all prior forms of therapy, which are identical across patients." Mark B. Leick, MD, lead author, oncologist, Mass General Brigham Cancer Institute For the study, Leick and his colleagues sequenced the entire genomes of more than 200 patients with aggressive lymphoma from two major clinical trials of CAR-T cell therapy. In one of the trials, patients with T cells with variants that silenced the STXBP2 gene tended to experience toxicity related to CAR-T cell therapy. In both clinical trials, variants in the ADAMTSL3 gene correlated with protection from treatment-related toxicity, and variants in the PTPN22 gene were strongly associated with enhanced CAR T-cell expansion, which correlates with effective therapy.

Original title: “Inherited genetics can influence safety and success of CAR-T cell therapy”

cross cultural adaptation of the university of north carolina genomic knowledge scale translation and psychometric validation in japanese populations

Original title: “Cross-Cultural Adaptation of the University of North Carolina Genomic Knowledge Scale: Translation and Psychometric Validation in Japanese Populations.”

primary hyperparathyroidism in pregnancy resulting in hypercalcemic crisis and acute pancreatitis a case report

Original title: “[Primary hyperparathyroidism in pregnancy resulting in hypercalcemic crisis and acute pancreatitis: A case report].”

visceral leishmaniasis with suspected autoimmune disease a report of 2 cases

Original title: “[Visceral leishmaniasis with suspected autoimmune disease: A report of 2 cases].”

biallelic sco2 variants presenting as motor predominant axonal neuropathy with complex iv deficiency

Original title: “Biallelic SCO2 Variants Presenting as Motor-Predominant Axonal Neuropathy With Complex IV Deficiency.”

targeted vntr long read sequencing resolves a diagnostic bottleneck in adtkd and detects de novo adtkd muc1

Original title: “Targeted VNTR long read sequencing resolves a diagnostic bottleneck in ADTKD and detects de novo ADTKD-MUC1.”

large scale whole exome sequencing defines the protein coding architecture of retinal structure visual function and major blinding diseases

Original title: “Large-scale Whole-Exome Sequencing Defines the Protein-Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases.”

acute onset bilateral myopia induced by hydrochlorothiazide

Original title: “Acute-onset bilateral myopia induced by hydrochlorothiazide.”

update to the classification evaluation and management of childhood interstitial lung disease in infancy an official american thoracic society clinical practice guideline

Original title: “An Update to the Classification, Evaluation, and Management of Childhood Interstitial Lung Disease in Infancy: An Official American Thoracic Society Clinical Practice Guideline.”

does surgical approach influence benchmark attainment in intrahepatic cholangiocarcinoma

Original title: “Does Surgical Approach Influence Benchmark Attainment in Intrahepatic Cholangiocarcinoma?”

podophyllotoxin induces testicular toxicity via the microbiota gut testis axis based on the toxicological evidence chain concept

Original title: “Podophyllotoxin induces testicular toxicity via the microbiota-gut-testis axis based on the toxicological evidence chain concept.”

ruxolitinib for life threatening corticosteroid refractory hypereosinophilic syndrome a multicenter case series

Original title: “Ruxolitinib for life-threatening corticosteroid-refractory hypereosinophilic syndrome: A multicenter case series.”

clinical efficacy and safety outcomes of anlotinib therapy in sarcoma a systematic review and meta analysis

Original title: “Clinical efficacy and safety outcomes of anlotinib therapy in sarcoma: a systematic review and meta-analysis.”

congenital external carotid internal carotid artery anastomosis associated with moyamoya disease diagnosed by magnetic resonance angiography

Original title: “Congenital external carotid-internal carotid artery anastomosis associated with moyamoya disease diagnosed by magnetic resonance angiography.”

babesiosis at ultra low parasitemia presenting as secondary hemophagocytic lymphohistiocytosis in a patient on b cell depleting therapy

Original title: “Babesiosis at ultra-low parasitemia presenting as secondary hemophagocytic lymphohistiocytosis in a patient on B cell-depleting therapy.”

follicular predominant pretibial flegel s disease a unilateral folliculocentric presentation expanding the dermoscopic spectrum

Original title: “Follicular-predominant pretibial Flegel's disease: a unilateral folliculocentric presentation expanding the dermoscopic spectrum.”

genomic epidemiology and clinical characteristics of linezolid resistant enterococcus faecalis in taiwan 2014 2020

Original title: “Genomic epidemiology and clinical characteristics of linezolid-resistant Enterococcus faecalis in Taiwan, 2014-2020.”

beyond distal arthrogryposis refining the phenotypic landscape of piezo2 related disorders

Original title: “Beyond distal arthrogryposis: refining the phenotypic landscape of PIEZO2-related disorders.”