immune checkpoint inhibitor therapy for treatment of periocular merkel cell carcinoma a systematic review of clinical outcomes and safety

Original title: “Immune checkpoint inhibitor therapy for treatment of periocular Merkel cell carcinoma: A systematic review of clinical outcomes and safety.”

evidence aggregator ai reasoning applied to rare disease diagnostics

Original title: “The Evidence Aggregator: AI reasoning applied to rare disease diagnostics.”

aqp4 nmosd mda5 clinically amyopathic dermatomyositis and shlh in a pediatric patient a case report and literature review

Original title: “AQP4+ NMOSD, MDA5+ Clinically Amyopathic Dermatomyositis and sHLH in a Pediatric Patient: A Case Report and Literature Review.”

malignancy associated hemophagocytic lymphohistiocytosis an experience of 15 years in polish pediatric hematology centers

Original title: “Malignancy-Associated Hemophagocytic Lymphohistiocytosis: An Experience of 15 Years in Polish Pediatric Hematology Centers.”

mechanism of age related accumulation of mtdna mutations in human blood

Original title: “Mechanism of age-related accumulation of mtDNA mutations in human blood.”

report 2 macular edema after acute retinal necrosis a difficult crossroad in management

Original title: “Report 2: Macular edema after acute retinal necrosis-A difficult crossroad in management.”

adult onset stills disease diagnosed in pregnancy

Original title: “Adult-Onset Stills Disease Diagnosed in Pregnancy.”

histiocytosis development and clinical variation through the lens of genomics

Original title: “Histiocytosis development and clinical variation through the lens of genomics.”

dosage of lipoproteins for risk management according to guidelines

Original title: “Dosage of lipoproteins for risk management according to guidelines.”

primary carcinoma of the rete testis in a nellore bull

Original title: “Primary carcinoma of the rete testis in a Nellore bull.”

Explore the potential of CAR-T therapy as a groundbreaking treatment for autoimmune diseases, offering long-term remission without lifelong immune suppression. CAR-T therapy involves extracting a patient’s T-cells, genetically engineering them in the laboratory to recognise specific targets, and then infusing them back into the body. In cancer treatment, these engineered cells attack malignant cells. In autoimmune disease, the target is different: rogue B-cells that mistakenly attack the body’s own tissues. Aishwarya G., consultant rheumatologist and clinical immunologist, Apollo Speciality Hospitals, said the idea emerged from observations in blood cancer treatment, where CAR-T therapy caused prolonged depletion of B-cells. She added that the therapy “aims to reprogramme the immune system itself,” creating the possibility of durable remission after a single treatment in refractory patients. Enhanced CAR-T therapy clears solid tumours by finding ‘faint’ targets · Experts caution that major scientific, clinical and financial barriers remain before CAR-T therapy becomes part of routine autoimmune care. Much of the interest in CAR-T therapy comes from early studies in Europe, particularly from research groups in Erlangen, Germany, where patients with severe lupus who did not respond to standard treatments achieved prolonged remission after a single infusion. Studies in lupus, inflammatory myositis and multiple sclerosis have reported patients remaining symptom-free for over a year without continuous immunosuppressive medication. Dr. Gopinath said CAR-T therapy has completed Phase 2 trials in conditions such as SLE and inflammatory myositis, with larger studies expected to expand further, including in India. Autoimmune diseases occur when the body’s immune system mistakenly attacks its own tissues. Conditions such as rheumatoid arthritis, systemic lupus erythematosus (SLE), multiple sclerosis and inflammatory myositis often require years of immunosuppressive treatment, exposing patients to infections, organ damage and cumulative side effects. Researchers are now studying whether CAR-T therapy,a personalised immune-cell treatment already used in blood cancers could change the way autoimmune disorders are treated.

Original title: “Understanding the potential of CAR-T therapy in autoimmune disease treatment - The Hindu”

subset of high grade sarcomas with myogenic differentiation are associated with recurrent fgfr fusions

Original title: “A subset of high-grade sarcomas with myogenic differentiation are associated with recurrent FGFR fusions.”

Detecting meaningful change in rare disease trials requires more than statistics—it demands the right COA. Discover why sensitivity matters and how AI is transforming trial outcomes.

Original title: “Measuring what matters: New priorities in COA selection”

pathogenic variants in the autophagy tethering factor epg5 drive neurodegeneration through mitochondrial dysfunction and innate immune activation

Original title: “Pathogenic variants in the autophagy-tethering factor EPG5 drive neurodegeneration through mitochondrial dysfunction and innate immune activation.”

artificial intelligence enhancement of flow cytometry data accelerates the identification of measurable residual chronic lymphocytic leukemia

Original title: “Artificial intelligence-enhancement of flow cytometry data accelerates the identification of measurable residual chronic lymphocytic leukemia.”

prediction of personalized therapeutic response in pediatric clivus chordoma chemoresistance test

Original title: “Prediction of personalized therapeutic response in pediatric clivus chordoma: chemoresistance test.”

mngie with tymp and polg variants presenting as decade long capsule retention a case report

Original title: “MNGIE with TYMP and POLG variants presenting as decade-long capsule retention: A case report.”

sequential infection of walled off pancreatic necrosis by salmonella typhi with secondary enterococcus avium superinfection following ercp a case report

Original title: “Sequential infection of walled-off pancreatic necrosis by Salmonella Typhi with secondary Enterococcus avium superinfection following ERCP: A case report.”