switching from intravenous to subcutaneous infliximab in children with inflammatory bowel disease a systematic review and meta analysis

Original title: “Switching from Intravenous to Subcutaneous Infliximab in Children with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.”

extramammary paget s disease with bilateral sentinel lymph node biopsy a multicenter study of lymphatic patterns and outcomes

Original title: “Extramammary Paget's Disease With Bilateral Sentinel Lymph Node Biopsy: a Multicenter Study of Lymphatic Patterns and Outcomes.”

CAR-T cell therapy, approved for some blood cancers, is being studied for lupus, MS, and scleroderma. Yale Medicine experts explain how it works, its risks, and who may qualify. Since 2017, the U.S. Food and Drug Administration (FDA) has approved seven CAR-T therapies, all for blood cancers. None is yet approved for an autoimmune disease. ... Collecting cells: A patient’s T cells are collected through apheresis, an outpatient procedure that filters specific cells from the bloodstream. Engineering cells: In a lab, the T cells are genetically modified to recognize a specific target. It may sound like science fiction: removing a person’s immune cells, modifying them in a lab, and putting them back into the body to target the cells causing disease. But medical experts believe the approach, known as chimeric antigen receptor T-cell (CAR-T) therapy, could someday help treat a growing list of hard-to-manage conditions. CAR-T cell therapy, a treatment that has transformed care for some people with leukemia and lymphoma, is now being studied in clinical trials for autoimmune diseases, including multiple sclerosis (MS), lupus, and scleroderma. Early results are encouraging, but the approach is still experimental. At Yale Cancer Center, specialists in hematology–oncology, rheumatology, and neurology are working together to study CAR-T therapy for MS, scleroderma, and lupus in clinical trials. The program began in August 2025, when the first patient with MS received CAR-T cells.

Original title: “CAR-T Cell Therapy Moves Beyond Cancer to Autoimmune Diseases | News | Yale Medicine”

outcomes of adult patients with mucopolysaccharidoses type treated by enzyme replacement therapy

Original title: “[Outcomes of adult patients with mucopolysaccharidoses type Ⅰ treated by enzyme replacement therapy].”

seronegative rheumatoid arthritis combined with elbow pigmented villonodular synovitis a case report

Original title: “[Seronegative rheumatoid arthritis combined with elbow pigmented villonodular synovitis: A case report].”

livedoid vasculopathy a case report

Original title: “[Livedoid vasculopathy: A case report].”

systemic sclerosis with anti human neutrophil cytoplasm antibody associated vasculitis a case report

Original title: “[Systemic sclerosis with anti-human neutrophil cytoplasm antibody associated vasculitis: A case report].”

whole exome and whole genome sequencing identifies driver ctnnb1 mutations in ossifying renal tumor of infancy

Original title: “Whole-Exome and Whole-Genome Sequencing Identifies Driver CTNNB1 Mutations in Ossifying Renal Tumor of Infancy.”

systematic review of clinical trials and cohort studies evaluating hiv post exposure prophylaxis pep regimens to inform updated canadian guidelines

Original title: “Systematic review of clinical trials and cohort studies evaluating HIV post-exposure prophylaxis (PEP) regimens to inform updated Canadian guidelines.”

longitudinal olfactory and neuropsychological trajectories across the gba1 spectrum

Original title: “Longitudinal olfactory and neuropsychological trajectories across the GBA1 spectrum.”

isavuconazole real world data and clinical considerations for pediatric patients

Original title: “Isavuconazole: Real-World Data and Clinical Considerations for Pediatric Patients.”

multimodal imaging features of nuclear protein in testis carcinoma of the submandibular gland a case report

Original title: “Multimodal imaging features of nuclear protein in testis carcinoma of the submandibular gland: a case report.”