adrenalectomy improves cardiovascular profile in patients with mild autonomous cortisol secretion extension of a multicenter randomized controlled trial to 12 months

Original title: “Adrenalectomy improves cardiovascular profile in patients with mild autonomous cortisol secretion: extension of a multicenter randomized controlled trial to 12 months.”

clinical outcomes of children with autoimmune hepatitis in korea a nationwide multicenter study

Original title: “Clinical Outcomes of Children With Autoimmune Hepatitis in Korea: A Nationwide Multicenter Study.”

red eye presentation concerning for vernal keratoconjunctivitis a case report

Original title: “A red-eye presentation concerning for vernal keratoconjunctivitis: a case report.”

elevated iron levels in tears of patients diagnosed with wdr45 x linked optic atrophy

Original title: “Elevated iron levels in tears of patients diagnosed with WDR45 X-linked optic atrophy.”

accuracy of muscle ultrasonography in detecting fasciculations for the diagnosis of amyotrophic lateral sclerosis a systematic review and meta analysis

Original title: “Accuracy of muscle ultrasonography in detecting fasciculations for the diagnosis of amyotrophic lateral sclerosis: a systematic review and meta-analysis.”

rare case of neonatal rib osteomyelitis diagnostic challenges and successful conservative management

Original title: “A Rare Case of Neonatal Rib Osteomyelitis: Diagnostic Challenges and Successful Conservative Management.”

gv 001 an oral available histone deacetylase 6 inhibitor for the treatment of autosomal dominant polycystic kidney disease

Original title: “GV-001, An Oral Available Histone Deacetylase 6 Inhibitor for the Treatment of Autosomal Dominant Polycystic Kidney Disease.”

Many researchers prefer the “live” data that comes from real-world results while still acknowledging potential shortcomings. The too old, the too sick generally remain outside the chosen parameters, not only for safety reasons, but because their illnesses and conditions can challenge and obscure the legitimacy of the tested therapy. Too much heterogeneity threatens regulatory approval. Too much homogeneity, however, creates its own problems; a thorough understanding of how real patients in the real world will respond to the treatment — risk vs benefit — isn’t likely to be ascertained in a clinical trial. While a real-world trial will not directly connect cause and effect, where so-called noise exists in abundance, it can expand the population that the therapy was created to help in the first place. “It is often the case that the treatment dilemmas we face in the clinic do not align perfectly with the current evidence base. Ryan is doctoral fellow, Institute of Health Informatics and ST4 Doctor in Clinical Pharmacology and Therapeutics, University College London. “There is growing appreciation for using alternative sources of data to give more complementary insights into a drug's treatment effect,” he said. Irl B. Hirsch, MD, professor, diabetes treatment and teaching chair, University of Washington School of Medicine and UW Medicine Diabetes Institute, is a fan of real-world trials. This program, said Fonarow, the Eliot Corday Chair in Cardiovascular Medicine and Science at UCLA, “has shown how guideline‑directed therapies perform in everyday hospitals — community, academic, rural, and urban — not just in highly selected trial populations.” · Clinicians, he said, can be confident that using “evidence‑based therapies for heart failure at scale is safe, well tolerated, and truly improve outcomes, including lower 30‑day mortality and better long‑term survival.”

Original title: “Clinical Trial Pools Are Often Homogenous. These Researchers Prefer Real-World Data”

chronic pulmonary aspergillosis in children a scoping global review

Original title: “Chronic Pulmonary Aspergillosis in Children: A Scoping Global Review.”

development of an exon 27 skipping antisense oligonucleotide as a targeted therapy for refractory skin ulcers in werner syndrome

Original title: “Development of an exon 27-skipping antisense oligonucleotide as a targeted therapy for refractory skin ulcers in Werner syndrome.”

malignant transformation of endometriosis a rare case of extrauterine endometrial stromal sarcoma

Original title: “Malignant Transformation of Endometriosis: A Rare Case of Extrauterine Endometrial Stromal Sarcoma.”

serotype distribution of streptococcus pneumoniae in children with invasive diseases in t rkiye 2019 2025 an update in the 10th to 15th years of routine pneumococcal conjugate vaccination

Original title: “Serotype distribution of Streptococcus pneumoniae in children with invasive diseases in Türkiye, 2019-2025: An update in the 10th to 15th years of routine pneumococcal conjugate vaccination.”

two decades of multimodal management of colorectal liver metastases with long term outcomes

Original title: “Two Decades of Multimodal Management of Colorectal Liver Metastases With Long-Term Outcomes.”

atypical fibro osseous lesion of maxilla possibility of brown tumour or hyperparathyroidism

Original title: “Atypical fibro-osseous lesion of maxilla: possibility of brown tumour or hyperparathyroidism.”

pericarditis arthritis camptodactyly syndrome four decades after its original description

Original title: “[Pericarditis, arthritis, camptodactyly syndrome: four decades after its original description].”

beyond pertussis bordetella holmesii bacteremia in children with sickle cell disease a case series with literature review

Original title: “Beyond Pertussis: Bordetella holmesii Bacteremia in Children With Sickle Cell Disease: A Case Series with Literature Review.”

pediatric intracranial abscesses in a tertiary care center antimicrobial management diagnostic yield of molecular testing and radiologic follow up

Original title: “Pediatric Intracranial Abscesses in a Tertiary Care Center: Antimicrobial Management, Diagnostic Yield of Molecular Testing and Radiologic Follow-Up.”

nrf2 regulates angiogenesis in spinal cystic echinococcosis via rtn4

Original title: “Nrf2 regulates angiogenesis in spinal cystic echinococcosis via RTN4.”

effect of managed transition on the proportion of young people transitioning from camhs to amhs analysis of the milestone cluster randomised clinical trial

Original title: “The effect of managed transition on the proportion of young people transitioning from CAMHS to AMHS: Analysis of the Milestone Cluster Randomised Clinical Trial.”

primary synovial sarcoma of the breast initially mimicking dermatofibrosarcoma protuberans a case report

Original title: “Primary Synovial Sarcoma of the Breast Initially Mimicking Dermatofibrosarcoma Protuberans: A Case Report.”