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Every story we pull is tagged to the disease it’s about — so you can filter to your condition and read only what matters.
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endovascular repair of an ilio iliac arteriovenous fistula presenting as acute lower limb edema
Original title: “Endovascular Repair of an Ilio-Iliac Arteriovenous Fistula Presenting as Acute Lower Limb Edema.”
rare causes of portal vein thrombosis and occlusion a narrative review
Original title: “Rare Causes of Portal Vein Thrombosis and Occlusion: A Narrative Review.”
pleomorphic rhabdomyosarcoma outcomes of patients with advanced disease treated with systemic agents retrospective study from the global pushing ultra rare sarcomas towards hope push consortium
Original title: “Pleomorphic rhabdomyosarcoma, outcomes of patients with advanced disease treated with systemic agents: Retrospective study from the global pushing ultra-rare sarcomas towards hope (PUSH) consortium.”
halos and hemoptysis a case of intrapulmonary sequestration masquerading as a pulmonary aspergilloma
Original title: “Halos and Hemoptysis: A Case of Intrapulmonary Sequestration Masquerading as a Pulmonary Aspergilloma.”
sotatercept for decompensated pulmonary arterial hypertension requiring va ecmo first canadian icu experience
Original title: “Sotatercept for Decompensated Pulmonary Arterial Hypertension Requiring VA ECMO: First Canadian ICU Experience.”
do different organ involvements cause different comorbidity profiles in beh et s syndrome
Original title: “Do different organ involvements cause different comorbidity profiles in Behçet's syndrome?”
genomic and transcriptomic analysis of salivary adenoid cystic carcinomas defines molecular subtypes
Original title: “Genomic and Transcriptomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes.”
crooke cell adenoma is its aggressiveness overestimated evidence from a single centre experience
Original title: “Crooke Cell Adenoma: Is Its Aggressiveness Overestimated? Evidence From a Single-Centre Experience.”
primary pulmonary epithelioid hemangioendothelioma a clinicopathological analysis of 40 cases
Original title: “[Primary pulmonary epithelioid hemangioendothelioma: a clinicopathological analysis of 40 cases].”
Clinical trials advance our understanding of human biology, establish the safety and effectiveness of new drugs and devices prior to broad use, fill therapy gaps for rare and chronic conditions and drive medical progress. They are the backbone of medical innovation, having more impact on human health than most people realize. ... only 5% of the 7,000 rare diseases currently have treatment ... Clinical trials advance our understanding of human biology, establish the safety and effectiveness of new drugs and devices prior to broad use, fill therapy gaps for rare and chronic conditions and drive medical progress. They are the backbone of medical innovation, having more impact on human health than most people realize. ... only 5% of the 7,000 rare diseases currently have treatment options. The convergence of AI, decentralized technologies, behavioral science, and real-world evidence opens the door to a new era in which the clinical trial industry proactively addresses participation barriers, integrates social determinants of health, and reimagines patient centricity. For example, after years of lengthening timelines, median enrollment durations stabilized in 2024 and inter-trial delays (the time between trials in a development program) dropped sharply, from a peak of 32 months in 2022 down to 17 months. By accelerating the adoption of AI and agentic AI workflows, clinical life sciences organizations not only gain operational efficiency and a competitive edge, but they also advance the shared mission of delivering life-saving treatments to patients more quickly, safely, and effectively. Certain steps within the trial lifecycle, such as recruitment, retention and safety monitoring, are particularly prone to costly bottlenecks that can delay or derail trials, ultimately jeopardizing patient experiences. Artificial intelligence (AI) offers a new path forward for clinical trial sponsors, contract research organizations (CROs), and research sites collaborating on trials.
Original title: “AI in Action: Breaking Down Clinical Trial Bottlenecks | Applied Clinical Trials Online”
real world effectiveness and safety of ravulizumab in patients with paroxysmal nocturnal hemoglobinuria evidence from the international pnh registry
Original title: “Real-World Effectiveness and Safety of Ravulizumab in Patients With Paroxysmal Nocturnal Hemoglobinuria: Evidence From the International PNH Registry.”
crossing the finish line towards a disease modifying treatment for angelman syndrome
Original title: “Crossing the finish line towards a disease-modifying treatment for Angelman syndrome.”
varicella zoster virus related myelitis a case series and literature review
Original title: “Varicella zoster virus-related myelitis: a case series and literature review.”
is a variant of uncertain significance always insignificant a systematic review on prf1 a91v in hemophagocytic lymphohistocytosis and comparative analysis with still s disease
Original title: “Is a variant of uncertain significance always 'insignificant'? A systematic review on PRF1 A91V in Hemophagocytic Lymphohistocytosis and comparative analysis with Still's disease.”
conceptual disease model of symptoms and impacts in adults with prurigo nodularis a qualitative and literature informed study
Original title: “A Conceptual Disease Model of Symptoms and Impacts in Adults with Prurigo Nodularis: A Qualitative and Literature-Informed Study.”
acquired epidermodysplasia verruciformis in patients with iatrogenic immunosuppression
Original title: “Acquired Epidermodysplasia Verruciformis in Patients with Iatrogenic Immunosuppression.”
warm autoimmune hemolytic anemia in adults in latin america a scoping review
Original title: “Warm autoimmune hemolytic anemia in adults in Latin America: A scoping review.”
osgep associated galloway mowat syndrome a longitudinal genotype phenotype correlation from prenatal imaging markers to lifespan neurologic renal trajectories
Original title: “OSGEP-Associated Galloway-Mowat Syndrome: A Longitudinal Genotype-Phenotype Correlation from Prenatal Imaging Markers to Lifespan Neurologic-Renal Trajectories.”
risk factors for pseudomyxoma peritonei in appendiceal mucinous neoplasms a single center experience
Original title: “Risk Factors for Pseudomyxoma Peritonei in Appendiceal Mucinous Neoplasms: A Single-Center Experience.”
patient and caregiver perspectives on neurodevelopmental and mental health care for rasopathies
Original title: “Patient and caregiver perspectives on neurodevelopmental and mental health care for RASopathies.”